N-乙烯基咔唑的合成新工艺研究  

New Synthetic Process of N-Vinylcarbazole

作　　者：刘长春 周洋 申志浩 柴存才[1] 陈杰英[1] 陈瑨[1] LIU Changchun;ZHOU Yang;SHEN Zhihao;CHAI Cuncai;CHEN Jieying;CHEN Jin(Institute of Chemistry Co.Ltd.,Henan Academy of Sciences,Zhengzhou 450002,China)

机构地区：[1]河南省科学院化学研究所有限公司,郑州450002

出　　处：《河南科学》2020年第6期886-890,共5页Henan Science

基　　金：河南省科学院杰青人才培养项目(200403007);河南省基本科研业务费项目(200603026)。

摘　　要：首次以咔唑和甲基丁炔醇为原料,在氢氧化钾(KOH)碱性条件下反应,合成了高纯度的N-乙烯基咔唑,并对反应条件进行了优化.结果表明:咔唑、甲基丁炔醇、KOH的摩尔比为1∶1.1∶1.1,反应溶剂为乙醇,反应温度为78℃回流,反应时间2.5 h,产物产率最高可以达到81.3%,纯度为99.5%.该合成方法反应条件温和,操作简便,产物产率高,适合工业化生产.For the first time,carbazole and methylbutynol were used as raw materials,and high-purified Nvinylcarbazole was synthesized under KOH basic conditions.The screening optimization results were obtained as follow:The molar ratio n(carbazole)∶n(methylbutynol)∶n(KOH)=1∶1.1∶1.1,ethanol as the solvent,reaction temperature 78℃,reaction time 2.5 h.The highest yield of the product can reach 81.3%and the purity was 99.5%.The method is suitable for industrial production because of its mild reaction conditions,simple operation and high yield.

关 键 词：甲基丁炔醇 合成 N-乙烯基咔唑 

分 类 号：O625.46[理学—有机化学]