间苯三酚与阿托西班在反复种植失败者行解冻胚胎移植的比较研究  

Effect of phloroglucinol vs atosiban on frozenembryo transfer in subjects with repeated implantation failure

作　　者：土增荣[1] 高瑞璠 王丽媛[1] 段瑞云[1] 张红梅[1] 田秀珠[1] 王艳红[1] Tu Zengrong;Gao Ruifan;Wang Liyuan;Duan Ruiyun;Zhang Hongmei;Tian Xiuzhu;Wang Yanhong(Reproductive Medicine Center,First Affiliated Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院生殖医学中心,太原030001

出　　处：《中国药物与临床》2020年第11期1765-1767,共3页Chinese Remedies & Clinics

基　　金：山西省重点研发计划(指南)项目(201603D321071)。

摘　　要：目的观察间苯三酚与阿托西班在反复种植失败(RIF)者行解冻胚胎移植(FET)的临床效果。方法回顾性分析在山西医科大学第一医院生殖医学中心行FET的RIF患者258例,分为3组。A组89例,为间苯三酚组,FET前1 h静脉推注80 mg间苯三酚;B组82例,FET前1 h静脉输注37.5 mg阿托西班;C组87例为对照组,只给予一般治疗。比较3组患者的胚胎着床率、临床妊娠率、流产率及异位妊娠率。结果与C组相比,A组,B组的胚胎着床率、临床妊娠率、多胎率明显较高(P<0.05)。A、B组相比差异无统计学意义。流产率及异位妊娠率3组比较差异无统计学意义。结论间苯三酚与阿托西班在RIF者行FET可以提高胚胎着床率和临床妊娠率,二者没有明显差异,但间苯三酚比较经济,可首选。Objective To investigate the clinical effect of phloroglucinol vs atosiban on frozen embryo transfer(FET)in subjects with repeated implantation failure(RIF).Methods A retrospective analysis was performed on 258 RIF patients who underwent FET in the Reproductive Medicine Center of First Affiliated Hospital of Shanxi Medical University.The subjects were divided into three groups:group A(phloroglucinol group,n=89)where the patients received 80 mg phloroglucinol intravenously at 1 h before FET,group B(n=82)where the patients received 37.5 mg atosiban intravenously at 1 h before FET,and group C(n=87,control group)where the patients received general care only.The embryo implantation rate,clinical pregnancy rate,miscarriage rate and ectopic pregnancy rate were com-pared among the three groups.Results Compared with group C,groups A and B had significantly higher rates of embryo implantation,clinical pregnancy,and multiple pregnancy(P<0.05),but there was no significant difference in these rates between groups A and B.There was no significant difference among the three groups in miscarriage and ectopic pregnancy.Conclusion Both phloroglucinol and atosiban may increase embryo implantation rate and clinical pregnancy rate in patients with RIF undergoing FET.However,phloroglucinolis more costly and should be used as the first-line choice.

关 键 词：间苯三酚 阿托西班 反复种植失败 解冻胚胎移植 

分 类 号：R714.8[医药卫生—妇产科学]