作为药物载体金属有机框架的功能化材料研究进展  

Research Progress on Functional Materials as Metal Organic Frameworks for Drug Carriers

作　　者：韩莎莎 赵僧群 刘冰弥[1,2] 刘宇[1,3] 李丽[1,3] HAN Shasha;ZHAO Sengqun;LIU Bingmi;LIU Yu;LI Li(School of Pharmacy,Liaoning University,Liaoning University,Shenyang 110036,China;Liaoning Pharmaceutical Engineering Research Center for Natural Medicine,Liaoning University,Shenyang 110036,China;Liaoning Key Laboratory of New Drug Research&Development,Liaoning University,Shenyang 110036,China)

机构地区：[1]辽宁大学药学院,辽宁沈阳110036 [2]辽宁大学辽宁省天然产物制药工程技术研究中心,辽宁沈阳110036 [3]辽宁大学辽宁省新药研发重点实验室,辽宁沈阳110036

出　　处：《中国材料进展》2020年第6期480-486,共7页Materials China

基　　金：辽宁省自然科学基金资助项目(材料联合基金)(20180510016)。

摘　　要：金属有机框架(MOFs)是一类新兴的材料,也称为配位聚合物,具有许多作为药物载体所需的特性,近年来已经成为药物存储和传递重要的候选材料。通常合成的纳米MOFs难以满足其在生物医学中的应用,通过表面修饰可以提高MOFs的稳定性和分散性,可以协助药物跨过生理障碍,实现MOFs的口服给药;另外通过表面改性也可以减缓MOFs的降解,实现缓释给药;通过进一步修饰还可以增加药物在特定部位的富集,实现靶向治疗。表面修饰对于MOFs药物传输系统的发展非常重要。近年来,比较常见的MOFs表面修饰材料有聚乙二醇、二氧化硅、环糊精、肝素、壳聚糖,以及其他靶向修饰材料,如叶酸、DNA、甘草次酸等。介绍了药物载体MOFs常见的表面修饰材料,及通过这些材料修饰后赋予MOFs的优良性能,并举例阐述了修饰后的MOFs在生物医药领域的应用前景,为MOFs作为药物载体的开发提供参考。Metal organic frameworks(MOFs)are a new type of material,known as coordination polymer.MOFs have many characteristics as drug carriers and have become an important candidate material for drug storage and delivery in recent years.Generally,the synthesized nanometer MOFs are difficult to meet their applications in biomedicine.Surface modification can improve the stability and dispersion of MOFs,which can help drugs overcome physiological barriers and realize oral administration of MOFs.In addition,the degradation of MOFs can be slowed down by surface modification to realize slow release.Further modification can also increase the enrichment of drugs at specific sites to achieve targeted therapy.Surface modification is important for the development of MOFs drug delivery systems.In recent years,relatively common MOFs surface modification materials include polyethylene glycol,silicon dioxide,cyclodextrin,heparin,chitosan,and other targeted modification materials,such as folic acid,DNA,glycyrrhizin,etc.In this paper,the functional modification materials commonly used in MOFs and the excellent properties of MOFs were introduced.The application prospect of modified MOFs in the field of medicine was illustrated with examples to provide references for the development of drug carrier MOFs.

关 键 词：金属有机框架(MOFs) 表面修饰 药物载体 药物传输系统 新兴材料 

分 类 号：R318.08[医药卫生—生物医学工程]