羟基磷灰石纳米粒子表面修饰的研究进展  

Research Progress on Surface Modification of Hydroxyapatite Nanoparticles

作　　者：范依然 闫文馨 韩颖超[2] FAN Yi-ran;YAN Wen-xin;HAN Ying-chao(International School of Materials Science and Engineering,Wuhan University of Technology,Wuhan 430070,China;State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,Wuhan University of Technology,Wuhan 430070,China)

机构地区：[1]武汉理工大学材料科学与工程国际化示范学院,武汉430070 [2]武汉理工大学材料复合新技术国家重点实验室,武汉430070

出　　处：《表面技术》2020年第7期17-27,共11页Surface Technology

基　　金：国家自然科学基金(51672206);先进能源科学与技术广东省实验室佛山分中心(佛山仙湖实验室)开放基金(XHT2020-008)。

摘　　要：羟基磷灰石是人体骨骼和牙齿的主要无机成分,具有良好的生物相容性和生物活性,且能诱导骨组织的生长,促进组织缺损的修复,是性能优异的骨修复材料。近年来,纳米羟基磷灰石由于其独特的性能,在生物医学领域展现出新的应用功能。但是,为了发挥纳米羟基磷灰石独特的功能特性,常常需要对其进行表面修饰,以满足生物医学应用的条件和要求。从生物医学角度,针对羟基磷灰石纳米粒子在生物显影、DNA转染、药物递送、与高分子复合、促进成骨和抑菌等方面的应用,对羟基磷灰石纳米粒子的表面修饰研究进行论述,探讨相关表面修饰思路和技术及修饰应用效果。通过表面修饰,不仅可以提高羟基磷灰石纳米粒子的分散性和悬浮稳定性,提升药物装载能力和促进成骨能力,还可以赋予其生物显影能力、主动靶向功能和抑菌能力。总之,表面修饰是一种促进羟基磷灰石纳米粒子生物医学应用的有效手段。Hydroxyapatite is the main inorganic component of human bones and teeth.It is an excellent bone repair material,which has good biocompatibility and biological activity,and can induce the growth of bone tissue and promote the repair of tissue defect.In recent years,nano-hydroxyapatite has exhibited new application functions in the field of biomedicine due to its unique properties.However,in order to take advantage of the unique functional properties of nano-hydroxyapatite,it is often necessary to modify its surface to meet the conditions and requirements of biomedical applications.From the perspective of biomedical applications,the research on surface modification of hydroxyapatite nanoparticles was reviewed for the applications in biological imaging,DNA transfection,drug delivery,compounding with polymers,promotion of bone formation and bacteriostasis,etc.Besides,the related surface modification ideas,techniques and application effects of modification were also discussed.The surface modification can not only improve the dispersibility and suspension stability as well as the drug loading capacity and promoting bone formation ability of hydroxyapatite nanoparticles,but also provide new functions including biological imaging ability,active targeting function and bacteriostatic ability.In short,the surface modification is an effective way to promote the biomedical application of hydroxyapatite nanoparticles.

关 键 词：羟基磷灰石 纳米材料 表面修饰 生物医学 

分 类 号：R318.08[医药卫生—生物医学工程]