多组学技术在中药毒性及解毒研究中的应用  

Application of multi-omics in toxicity and detoxification of Chinese materia medica

作　　者：曼琼 马骏 邓毅 李鹏杰 杨志军 杨秀娟 MAN Qiong;MA Jun;DENG Yi;LI Peng-jie;YANG Zhi-jun;YANG Xiu-juan(College of Pharmacy,Gansu College of Traditional Chinese Medicine,Lanzhou 730000,China;Gansu Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学药学院,甘肃兰州730000 [2]甘肃省中药药理与毒理学重点实验室,甘肃兰州730000

出　　处：《中草药》2020年第12期3117-3125,共9页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81960723);兰州市科技局资助项目(2018-4-63);甘肃省中药药理与毒理重点实验室开放基金资助项目(ZDSYS-KJ-2018-009)。

摘　　要：系统生物学的飞速发展为中医药深入研究提供了思路和手段,其可以全面系统地分析中药及复方多成分多靶点治疗疾病的分子机制。基于整合多组学策略研究中药毒性和解毒作用已成为中药安全性研究的方向和热点。对基因组学、转录组学、蛋白质组学、代谢组学和多组学整合技术在中药毒性及解毒作用和机制研究中的思路、方法和进展进行综述,为多组学技术在中药毒性及解毒作用深入研究中的应用提供参考。The rapid development of systems biology provides ideas and means for the in-depth study of Chinese materia medica(CMM).It can comprehensively and systematically analyze the molecular mechanism of CMM and Chinese medicine prescription in treating diseases with multi-component and multi-target.It has become the direction and hot spot of the safety research on the toxicity and detoxification of CMM based on the integrated multi-omics strategy.In this paper,the ideas,methods and progress of genomics,transcriptomics,proteomics,metabonomics and multi-omics integration technology in the study of toxicity,detoxification and mechanism of CMM were reviewed,which provides reference for the in-depth study of multi-omics technology in toxicity and detoxification of CMM.

关 键 词：多组学 中药 毒性 解毒 蛋白质组学 代谢组学 

分 类 号：R285[医药卫生—中药学]