阿利吉仑联合血管紧张素Ⅱ受体拮抗剂对老年高血压性心肌病患者血压控制及左心室功能的影响  

Effects of aliskiren combined with angiotensinⅡreceptor antagonist on blood pressure control and left ventricular function in elderly patients with hypertensive heart disease

作　　者：刘娟 梁珍玲 谢晓华 LIU Juan;LIANG Zhen-ling;XIE Xiao-hua(Geriatrics department,the Third Hospital of Changsha,Changsha 410000,China)

机构地区：[1]长沙市第三医院老年医学科,长沙410000

出　　处：《中国处方药》2020年第7期108-109,共2页Journal of China Prescription Drug

摘　　要：目的探讨阿利吉仑联合血管紧张素Ⅱ受体拮抗剂对老年高血压性心肌病(HHD)患者血压控制、左心室功能的影响。方法选取某院2017年1月~2019年3月老年HHD患者82例,依据随机数字表法分为对照组、观察组,各41例。对照组采用血管紧张素Ⅱ受体拮抗剂治疗,观察组在对照组基础上采用阿利吉仑治疗。比较两组治疗前后血压控制情况[收缩压(SBP)、舒张压(DBP)]、左心室功能[左心室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)]、不良反应发生率。结果治疗后,观察组SBP、DBP、LVEDD、LVESD低于对照组,LVEF高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较无明显差异(P>0.05)。结论阿利吉仑联合血管紧张素Ⅱ受体拮抗剂治疗老年HHD患者,可有效控制血压,改善左心室功能,且安全性高。Objective To investigate the effects of aliskiren combined with angiotensinⅡreceptor antagonist on blood pressure control and left ventricular function in elderly patients with hypertensive heart disease(HHD).Methods Eighty-two elderly patients with HHD in our hospital(January 2017 to March 2019)were selected and divided into a control group and a study group according to the random number table method,with 41 cases in each group.The control group was treated with angiotensinⅡreceptor antagonist,and the study group was treated with aliskiren based on the control group.The blood pressure control[systolic blood pressure(SBP),diastolic blood pressure(DBP)],left ventricular function[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)],and incidence of adverse reactions were compared between the two groups before and after treatment.Results After treatment,the SBP,DBP,LVEDD,and LVESD of the study group were significantly lower than those of the control group,and LVEF was significantly higher than that of the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Aliskiren combined with angiotensinⅡreceptor antagonist can effectively control blood pressure and improve left ventricular function in elderly patients with HHD,and has high safety.

关 键 词：阿利吉仑 血管紧张素Ⅱ受体拮抗剂 老年 高血压性心肌病 血压控制 

分 类 号：R544.1[医药卫生—心血管疾病] R542.2[医药卫生—内科学]