不同剂量阿托伐他汀对微量白蛋白尿伴高脂血症患者尿微量白蛋白的影响  

Effect of different doses of atorvastatin on urinary microalbumin of patients with microalbuminuria and hyperlipidemia

作　　者：张震洪[1] 严俊儒[1] ZHANG Zhen-hong;YAN Jun-ru(Foshan Second People's Hospital,Guangdong 528000,China)

机构地区：[1]佛山市第二人民医院,广东佛山528000

出　　处：《中国处方药》2020年第7期127-128,共2页Journal of China Prescription Drug

基　　金：广东省组织构建与检测重点实验室开放基金(zzgjzd2019007);佛山市十三五医学重点专科建设项目(心内科,FSZDZK135027)。

摘　　要：目的观察不同剂量的阿托伐他汀钙干预3个月、6个月对微量白蛋白尿伴高脂血症患者尿微量白蛋白的影响。方法选择在医院治疗的微量白蛋白尿伴高脂血症患者248例,分为常规剂量治疗组(阿托伐他汀20 mg/d+常规治疗,n=82)、低剂量治疗组(阿托伐他汀10 mg/d+常规治疗,n=80)和对照组(常规治疗,n=86),比较试验开始、治疗3个月、6个月的尿微量白蛋白/肌酐比值。结果试验开始,常规剂量治疗组、低剂量治疗组、对照组的尿微量白蛋白/肌酐比值分别是(167.59±13.22)mg/g、(159.04±20.92)mg/g、(162.04±25.56)mg/g;治疗3个月时,三组的尿微量白蛋白/肌酐比值分别是(158.69±17.42)mg/g、(152.34±10.42)mg/g、(159,34±9.97)mg/g;治疗6个月后,3组的尿微量白蛋白/肌酐比值分别是(128.77±9.40)mg/g、(144.87±18.21)mg/g、(156.89±10.87)mg/g。常规剂量治疗组的患者使用阿托伐他汀干预3个月时,尿微量白蛋白/肌酐比值呈现下降趋势,差异有统计学意义(P<0.05),6个月时,尿微量白蛋白/肌酐比值显著下降,差异有统计学意义(P<0.05);对照组、低剂量治疗组使用阿托伐他汀干预3个月、6个月,尿微量白蛋白/肌酐比值差异无统计学意义(P>0.05)。结论早期、足剂量、足疗程的他汀干预可望降低尿微量白蛋白,改善肾功能。Objective To observe the effects of different doses of atorvastatin on microalbuminuria of patients with microalbuminuria and hyperlipidemia at 3,6 month of trail.Methods 248 patients with microalbuminuria and hyperlipidemia treated in the second people’s Hospital of Foshan were divided into the routinedose treatment group(atorvastatin 20 mg/day+conventional treatment,n=82),the low-dose treatment group(atorvastatin 10 mg/day+conventional treatment,n=80)and the control group(conventional treatment,n=86).Urinary albumin/creatinine ratio at the beginning,three and six months of the trial were compared.Results At the beginning of the trail,Urinary albumin/creatinine ratio in the conventional treatment group,the low-dose treatment group and the routine-dose were(167.59±13.22)mg/g vs.(159.04±20.92)mg/g vs.(162.04±25.56)mg/g.At the three months of the trail,urinary albumin/creatinine ratio of three groups were(158.69±17.42)mg/g vs.(152.34±10.42)mg/g vs.(159.34±9.97)mg/g.At the six months of the trail,urinary albumin/creatinine ratio of three groups were(128.77±9.40)mg/g vs.(144.87±18.21)mg/g vs.(156.89±10.87)mg/g.After three months of atorvastatin intervention,Urinary albumin/creatinine ratio decreased non significantly(P>0.05);Urinary albumin/creatinine decreased significantly(P<0.05)after 6 months;However,Urinary albumin/creatinine ratio of other two groups did not change significantly after three,six months intervention.(P>0.05).Conclusion Early intervention of statins with sufficient dosage and treatment course is expected to reduce urinary microalbumin and improve renal function.

关 键 词：阿托伐他汀 尿微量白蛋白 高脂血症 

分 类 号：R589.2[医药卫生—内分泌]