氯唑西林钠的溶解度和晶习分析研究  

Study on the solubility and crystal habit of cloxacillin sodium

作　　者：智敏杰 陈亮[1] ZHI Min-jie;CHEN Liang(School of Public Security,Northwest University of Political Science and Law,Xi’an 710122,China)

机构地区：[1]西北政法大学公安学院,陕西西安710122

出　　处：《高校化学工程学报》2020年第3期611-618,共8页Journal of Chemical Engineering of Chinese Universities

摘　　要：为了解决氯唑西林钠晶习不完整导致产品质量不合格的问题,并为优化结晶工艺提供基础数据,采用动态法测定了氯唑西林钠在无水乙醇、丙醇、异丙醇、丙酮溶剂体系中的溶解度,并分别考察了不同溶剂体系对氯唑西林钠晶习的影响,对不同晶习的产品进行了X射线粉末衍射(XRD)和热重分析(TG-DTA)。结果表明:在上述4种纯溶剂体系中,氯唑西林钠的溶解度均随温度的升高而增大,溶解度数据用Apelblat热力学方程拟合结果良好。在不同溶剂体系中得到的氯唑西林钠的最优晶习为片状晶习,不同晶习的氯唑西林钠晶体为同一晶型,脱水温度为163℃。The solubility of cloxacillin sodium in ethanol,1-propanol,isopropanol,and acetone was measured by a dynamic method to solve the problem of unqualified domestic cloxacillin sodium induced by imperfect crystal habit,and to provide basic data for optimizing crystallization processes.Effects of solvent system on the crystal habit of cloxacillin sodium were studied.The products obtained were measured by X-ray diffraction spectrum and thermogravimetric analysis.The results show that the solubility increases with the increase of temperature.The solubility data were fitted well by the Apelblat thermodynamic equation.The best crystal habit obtained at the considered four solvent systems is the slice crystal.These products with different crystal habits have the same crystal form,and the dehydration temperature is 163℃.

关 键 词：氯唑西林钠 溶解度 晶习 X射线粉末衍射 热重分析 

分 类 号：TQ016.1[化学工程]