火神山医院146例新型冠状病毒肺炎康复者特异性IgM、IgG抗体定量检测与分析  

Quantitative Assay and Analysis of Specific IgM and IgG Antibodies in 146 Convalescent Patients with COVID-19 in Huoshenshan Hospital in Wuhan

作　　者：张兵华 许朝晖 王娟 李双双 郭玮 雷燕 郭永博 陈亚强 李照辉 王晓坤 谢晓燕 ZHANG Bing-hua;XU Zhao-hui;WANG Juan;LI Shuang-shuang;GUO Wei;LEI Yan;GUO Yong-bo;CHEN Ya-qiang;LI Zhao-hui;WANG Xiao-kun;XIE Xiao-yan(Department of Respiratory Diseases,the 986th Hospital of PLA Air Force,Xi'an 710054,China;Department of Infection Prevention and Control,the 986th Hospital of PLA Air Force,Xi'an 710054,China;Department of Critical Care Medicine,the 986th Hospital of PLA Air Force,Xi'an 710054,China;the Third Department of Infection Diseases,Huoshenshan Hospital of Wuhan,Wuhan 430000,China)

机构地区：[1]中国人民解放军空军第九八六医院呼吸科,西安710054 [2]中国人民解放军空军第九八六医院感染预防控制科,西安710054 [3]中国人民解放军空军第九八六医院重症医学科,西安710054 [4]武汉火神山医院感染三科,武汉430000

出　　处：《解放军医药杂志》2020年第7期1-4,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的探讨新型冠状病毒肺炎康复者新型冠状病毒(2019 noval coronavirus,2019-nCoV)特异性IgM、IgG抗体的产生规律。方法收集2020年2月10日-3月10日收治的146例新型冠状病毒肺炎康复者的血液标本,依据发病时间到标本采集时间分为A组20例、B组58例、C组46例、D组22例,发病时间分别为≤30 d、31~39 d、40~49 d、≥50 d。检测4组2019-nCoV特异性IgM、IgG抗体浓度。结果B、C、D组IgG抗体浓度高于A组,且C、D组高于B组(P<0.05,P<0.01),而4组IgM抗体浓度比较差异无统计学意义(P>0.05)。C、D组IgG抗体浓度比较差异无统计学意义(P>0.05)。结论新型冠状病毒肺炎康复者IgM、IgG抗体浓度均增高,且持续时间较长。IgM抗体浓度随发病时间的延长有下降趋势,IgG抗体浓度随发病时间的延长而逐步增高,发病50 d后仍维持较高水平。Objective To investigate regularity of specific immunoglobulin M(IgM)and immunoglobulin G(IgG)antibodies of novel coronavirus(2019-nCoV)in convalescent patients with corona virus disease 2019(COVID-19).Methods Blood samples of 146 convalescent patients with COVID-19 admitted from February 10 to March 102020 were collected.and the patients were divided into group A(n=20),group B(n=58),group C(n=46)and group D(n=22)according to times from onset to specimen collection,and days of onset were equal or less than 30 days,31-39 days,40-49 days and larger than or equal 50 days respectively.Concentrations of specific IgM and IgG antibodies of 2019-nCoV were detected in four groups.Results IgG antibody concentrations in group B,C and D were significantly higher than that in group A,and the concentrations in group C and D were significantly higher than that in group B(P<0.05,P<0.01).There were no significant differences in IgM antibody concentrations of 2019-nCoV among four groups(P>0.05).There was no significant difference in IgG antibody concentration between group C and D(P>0.05).Conclusion IgM and IgG antibody concentrations in convalescent patients with COVID-19 are increased with long unremitting time.IgG antibody concentration is increased,while IgM antibody concentration is decreased with prolonging onset time,and the concentrations keep high levels in the 50 th days after onset.

关 键 词：新型冠状病毒肺炎 COVID-19 SARS-CoV-2 IGM抗体 IGG抗体 康复期 

分 类 号：R563.1[医药卫生—呼吸系统]