经皮吸收制剂三七膜剂的制备工艺研究  

Research on the Preparation Process of Percutaneous Absorption Preparation Sanqi Coating Agents

作　　者：刘世军 张盘 唐志书 张娱 宋忠兴 崔春利 刘红波 许洪波 梁艳妮 LIU Shijun;ZHANG Pan;TANG Zhishu;ZHANG Yu;SONG Zhongxing;CUI Chunli;LIU Hongbo;XU Hongbo;LIANG Yanni(Shaanxi University of Chinese Medicine/Shaanxi Collaborative Innovation Centerof Chinese Medicinal Resource Industrialization of Shaanxi University of Chinese Medicine,Xianyang 712083,China;Shaanxi Research Center of Innovation Medicine;Shaanxi Provincial Engineering Research Center of Rheumatism and Tumor Chinese Drugs Preparation)

机构地区：[1]陕西中医药大学/陕西省中药资源产业化协同创新中心,陕西咸阳712083 [2]陕西省创新药物研究中心 [3]陕西省风湿与肿瘤类中药制剂工程技术研究中心

出　　处：《西部中医药》2020年第5期33-35,共3页Western Journal of Traditional Chinese Medicine

基　　金：陕西省科技统筹创新工程计划项目(2015KTCL03-14);陕西省教育厅服务地方专项计划项目(15JF001);中药产业过程大学生创新实践基地项目(陕教财〔2013〕171号);陕西省中医药管理局面上项目(ZYMS025);陕西省创新人才推进计划-科技创新团队(2018TD-005)。

摘　　要：目的:考察经皮吸收制剂三七膜剂的制备工艺。方法:用聚乙烯醇05-88与聚乙烯醇17-88作为成膜材料,甘油作为增塑剂,吐温80作为表面活性剂在单因素实验的基础上用正交实验L9(33)进行基质处方的筛选,考察制成膜剂的柔软性、光滑性、色泽透明度、均匀性,最后得出最佳基质处方比例。结果:经筛选得出的最佳基质处方为:PVA05-881.0 g,PVA17-883.0 g,甘油4.0 g,吐温802.0 g。结论:通过正交实验筛选所得的基质中加入三七提取物后其柔软性、光滑性、色泽透明度、均匀性较好;该三七膜剂的制备工艺简单、可行。Objective:To survey the preparation process of percutaneous absorption preparation Sanqi(notoginseng radix et rhizoma)coating agents.Methods:Polyvinyl alcohol 05-88 and polyvinyl alcohol 17-88 as the coating forming materials,glycerol as plasticizer and polysorbate80 as surface active agent were used to screen the matrixprescription by orthogonal test L9(33)on the foundation of single-factor test,to investigate the softness,smoothness,color transparency and uniformity of the coating agents,and finally to obtain the best matrix prescription ratio.Results:The best matrix prescription through screening were:PVA05-881.0 g,PVA17-883.0 g,glycerol 4.0 g and polysorbate 802.0 g.Conclusion:The matrix obtained and screened by orthogonal test L9(33)show better softness,smoothness,color transparency and uniformity and others after adding Sanqi extracts,the preparation process of Sanqi coating agents are simple and feasible.

关 键 词：三七 膜剂 经皮吸收 制备方法 正交实验 

分 类 号：R283.6[医药卫生—中药学]