蛹虫草提取物泡腾片的制备工艺优化及其质量分析  

Optimization of Preparation Process and Quality Analysis of Cordyceps militaris Extract Effervescent Tablets

作　　者：樊桂灵 周翔宇 钱叶迁 李玉锋 FAN Gui-ling;ZHOU Xiang-yu;QIAN Ye-qian;LI Yu-feng(College of Food and Bioengineering,Xihua University,Chengdu 610039,Sichuan,China)

机构地区：[1]西华大学食品与生物工程学院,四川成都610039

出　　处：《食品研究与开发》2020年第15期100-106,共7页Food Research and Development

基　　金：西华大学研究生创新基金项目(ycjj2018057)。

摘　　要：为制备蛹虫草提取物泡腾片,以感官评价、崩解时限、硬度为考察指标,利用正交试验优化蛹虫草提取物添加量、泡腾崩解剂酸碱比例、泡腾崩解剂总质量以及甜味剂添加量,采取酸碱混合非水制粒的方法制得蛹虫草提取物泡腾片,并对其进行质量分析.正交试验结果表明,制备泡腾片原辅料最佳配比为:蛹虫草提取物11%、柠檬酸和碳酸氢钠的比例1.3:1(质量比)、泡腾崩解剂总质量50%、甜味剂阿斯巴甜0.25%.按最佳工艺制得的泡腾片外观光滑完整,大小和色泽均匀,溶液澄清透明呈酸性,味道酸甜可口,并伴有蛹虫草特有香味,平均硬度在50 N以上,发泡量为23.95 mL/g,重量差异、崩解时限均符合2015年版中国药典要求,虫草多糖含量为10.01 mg/g,虫草素含量为0.65 mg/g.In order to prepare the effervescent tablets of Cordyceps militaris extract,the sensory evaluation,the time limit of disintegration and the hardness were used as indicators.The orthogonal test was used to optimize the addition amount of Cordyceps militaris extract,acid-base ratio of effervescent disintegrant,the total amount of effervescent disintegrants,and the addition amount of sweetener.The effervescent tablet of Cordyceps militaris extract was prepared by the method of non-aqueous granulation after acid-base mixing,and its quality was analyzed.The results of orthogonal test showed that the optimum proportion of the raw and auxiliary materials for the preparation of effervescent tablets was as follows:Cordyceps militaris extract 11%,the ratio of citric acid to sodium bicarbonate 1.3∶1(mass ratio),the total mass of effervescent disintegrants 50%and the sweetener aspartame 0.25%.The effervescent tablets prepared according to the best process had smooth and complete appearance,uniform size and color,clear,transparent and acid solution,sweet and sour taste,and special fragrance of Cordyceps militaris.The average hardness was more than 50 N,the foaming amount was 23.95 mL/g,the weight difference and disintegration time met the requirements of 2015 edition of Chinese Pharmacopoeia.The content of Cordyceps polysaccharides was 10.01 mg/g,and the content of cordycepin was 0.65 mg/g.

关 键 词：蛹虫草提取物 泡腾片 正交试验 制备工艺 质量分析 

分 类 号：TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]