基于《中华医典》的溃疡性结肠炎药性、药理研究  

Research on Drug Properties and Pharmacology of Ulcerative Colitis Based on Chinese Medical Classics

作　　者：白垚 王少辉 张家墉 马小兵 王喜霞 BAI Yao;WANG Shaohui;ZHANG Jiayong;MA Xiaobing;WANG Xixia(Shaanxi University of Chinese Medicine,Xianyang 712046,China;Affiliated Hospital of Shaanxi University of Chinese Medicine;The Second Affiliated Hospital of Shaanxi University of Chinese Medicine;Dingxi City Hospital of TCM)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学附属医院 [3]陕西中医药大学第二附属医院 [4]定西市中医院

出　　处：《西部中医药》2020年第4期74-78,共5页Western Journal of Traditional Chinese Medicine

基　　金：陕西省重点研发计划(2019SF-155)。

摘　　要：目的:利用关联分析揭示历代医家治疗痢疾药物的药性与药理作用,为溃疡性结肠炎的辨证论治提供遣药组方方面的依据。方法:检索并整理出《中华医典》辞典条下"名方"中治疗痢疾方剂的用药,利用Microsoft Office Excel 2016建立数据库,以IBM SPSS Modeler Version 18.0软件进行历代医家治疗痢疾高频药物药性、药理关联分析。结果:得到高频药物有46味,主要有甘草、黄连、当归、白芍、木香。高频药物药性以归脾经的甘、苦味温性为主要配伍组合,符合温-苦-甘-脾组合方式的高频药物为人参、白术。高频药物药理作用体现在抗菌与免疫调节两大方面,同时符合这两方面的高频药物有甘草、黄芩、黄连、黄柏、白芍、陈皮、茯苓、乌梅、白术。结论:研究结果与溃疡性结肠炎最新研究结果吻合,能够为溃疡性结肠炎的遣药组方提供临床依据。Objective:To provide the basis of the prescription for the differentiation and the treatment of ulcerative colitis(UC)through revealing drug properties and pharmacological action of the medicines in ancient doctors’treatment for dysentery using association analysis.Methods:The medications in the prescription of treating dysentery among the famous prescriptions were searched and collected from the items in Chinese medical classics,Microsoft Office Excel 2016 was used to establish the database,IBM SPSS Modeler Version 18.0 software was adopted to perform association analysis of drug properties and pharmacological action of high frequency drugs used by ancient doctors for dysentery.Results:All 46 kinds of high frequency herbs were obtained,and they were Gancao(glycyrrhizae radix et rhizoma),Huanglian(coptidis rhizoma),Danggui(angelicae sinensis radix),Baishao(paeoniae radix alba)and Muxiang(aicklandiae radix).High frequency herbs were of spleen meridian,sweet and bitter,warm nature mainly,the herbs which met the standard were Renshen(ginseng radix et rhizoma)and Baizhu(atractylodis macrocephalae rhizoma).Pharmacological action of high frequency herbs were reflected in two aspects:antibacterial and immune regulation,simultaneously,high frequency herbs which met the two aspects were Gancao,Huangqin(scutellariae radix),Huanglian,Huangbo(phellodendri chinensis cortex),Baishao,Chenpi(citri reticulatae pericarpium),Fuling(poria),Wumei(mume fructus)and Baizhu.Conclusion:Research results match the latest researches of UC,and it could provide clinical reference for clinical prescription of UC.

关 键 词：痢疾 溃疡性结肠炎 药性 药理作用 遣药组方 

分 类 号：R516.1[医药卫生—内科学]