BRD4、Ki-67、SSBP1水平与胃癌前病变进展的关系及在胃癌早期诊断中的价值  

Relationship between BRD4,Ki-67 and SSBP1 levels with progress of gastric precancerous lesions and their values in early diagnosis of gastric cancer

作　　者：张竹[1] 许乐[1] 贾文卓 ZHANG Zhu;XU Le;JIA Wenzhuo(Department of Digestion,Beijing Hospital/National Center of Gerontology/Institute of Geriatric Medicine,Chinese Academy of Medicial Sciences,Beijing 100730,China;Department of General Surgery,Beijing Hospital/National Center of Gerontology/Institute of Geriatric Medicine,Chinese Academy of Medicial Sciences,Beijing 100730,China)

机构地区：[1]北京医院/国家老年医学中心/中国医学科学院老年医学研究院消化科,北京100730 [2]北京医院/国家老年医学中心/中国医学科学院老年医学研究院普外科,北京100730

出　　处：《国际检验医学杂志》2020年第14期1703-1705,1709,共4页International Journal of Laboratory Medicine

摘　　要：目的分析溴结构域蛋白(BRD4)、核抗原Ki-67(简称Ki-67)、线粒体单链DNA结合蛋白(SSBP1)水平与胃癌前病变进展的关系及在胃癌早期诊断中的价值。方法选择2016年3月至2019年3月在该院普外科接受手术切除或消化内镜黏膜下剥离术(ESD)切除或胃镜活检获得胃组织的267例患者纳入本研究。其中胃组织包括早期胃癌组织82例,胃癌前病变组织135例,正常胃黏膜上皮组织50例。采用免疫组织化学法分析以上组织BRD4、Ki-67、SSBP1表达水平。结果正常胃黏膜、胃癌前病变和早期胃癌组织中Ki-67阳性率比较,差异有统计学意义(P<0.05)。正常胃黏膜、胃癌前病变和早期胃癌组织BRD4阳性率比较,差异有统计学意义(P<0.05)。正常胃黏膜、胃癌前病变和早期胃癌组织SSBP1阳性率比较,差异有统计学意义(P<0.05)。结论BRD4、Ki-67、SSBP1水平与胃癌前病变的进展存在一定的相关性,可作为预测胃癌前病变的潜在指标进行深入研究。Objective To analyze the relationship between bromodomain-containing protein 4(BRD4),Ki-67 and mitochondrial single-strand DNA-binding protein 1(SSBP1)levels with the progress of gastric precancerous lesions and their values in early diagnosis of gastric cancer.Methods The gastric tissue samples obtained by the operation excision or digestive endoscopic submucosal dissection(ESD)or gastroscopy biopsies in the general surgery department of this hospital from March 2016 to March 2019 were selected into the study,including 82 cases of early gastric cancer tissue,135 cases of gastric precancerous lesion tissue and 50 cases of normal gastric epithelial tissue.The expression levels of BRD4,Ki-67 and SSBP1 in these tissues were analyzed by adopting the immunohistochemical method.Results The positive rate of Ki-67 had statistical difference among normal gastric epithelial tissue,gastric precancerous lesion and early gastric cancer tissue(P<0.05).The positive rate of BRD4 had statistical difference among normal gastric epithelial tissue,gastric precancerous lesion and early gastric cancer tissue(P<0.05).The positive rate of SSBP1 had statistical difference among normal gastric epithelial tissue,gastric precancerous lesion and early gastric cancer tissue(P<0.05).Conclusion There is a certain correlation between BRD4,Ki-67 and SSBP1 levels with the progress of gastric precancerous lesions,which can serve as the potential indexes for predicting gastric precancerous lesions to conduct in-depth study.

关 键 词：溴结构域蛋白 核抗原Ki-67 线粒体单链DNA结合蛋白 胃癌前病变 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]