甲磺草胺及其关键中间体的合成方法综述  

Review on the Methods for Synthesis of Sulfentrazone and its Key Intermediates

作　　者：汪爱春 刘民华 全春生 王胜德 杜升华 党铭铭 WANG Ai-chun;LIU Min-hua;QUAN Chun-sheng;WANG Sheng-de;DU Sheng-hua;DANG Ming-ming(Hunan Haili Guixi Chemical Pesticide Co.,Ltd.,Guixi 335400,China;National Engineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry Co.,Ltd.,Changsha 410014,China;Hunan Province Key Laboratory for Agrochemicals,Changsha 410014,China;Department of Resources and Environment,Hunan Nonferrous Metals Vocational and Technical College,Zhuzhou 412000,China)

机构地区：[1]湖南海利贵溪化工农药有限公司,江西贵溪335400 [2]湖南化工研究院有限公司国家农药创制工程技术研究中心,湖南长沙410014 [3]农用化学品湖南省重点实验室,湖南长沙410014 [4]湖南有色金属职业技术学院资源环境系,湖南株洲412000

出　　处：《精细化工中间体》2020年第2期1-6,共6页Fine Chemical Intermediates

基　　金：国家自然科学基金项目(21672057);“十三·五”国家重点研发计划项目(2016YFD0300708);2018年湖南省有色金属管理局直属单位转型发展项目。

摘　　要：综述了甲磺草胺及其关键中间体的合成方法。甲磺草胺的合成方法主要有磺酰氯法、磺酸法、磺酸酯法、磺酰胺法及其它合成方法。磺酰氯法是最早合成甲磺草胺的经典方法,而磺酰胺法,尤其是以关键中间体5a与甲磺酰胺在含铜催化剂作用下直接合成甲磺草胺的方法具有原料易得、操作简便、收率高的优点,且能回避硝化反应及其间产生的废酸废水,有望成为甲磺草胺制备的新方法。The methods for synthesis of sulfentrazone and its key intermediates were reviewed.The synthetic methods for sulfentrazone can be concluded to sulfonyl chloride,sulfonic acid,sulfonate,sulfonamide and some other methods.Among them,the sulfonyl chloride method is the earliest classic method for the preparation of sulfentrazone.The sulfonamide method,especially the route from the key intermediate 5a and sulfonamide under copper-containing catalyst conditions may become a new alternative due to its prominent features such as starting materials easily obtained,easy industrialization operation and the high yield,as well as effectively avoiding the nitrification process and the large amounts of waste acid and waste water during the process.

关 键 词：甲磺草胺 除草剂 原卟啉原氧化酶抑制剂 合成方法 

分 类 号：S482.4[农业科学—农药学]