异噁草酮的合成研究  

Study on the Synthesis of Clomazone

作　　者：程超 欧阳宇迪 兰世林 刘源 熊莉莉 陈郭芹 徐健 CHENG Chao;OUYANG Yu-di;LANShi-lin;LIU Yuan;XIONG Li-li;CHEN Guo-qin;XU Jian(Hunan Research Institute of Chemical Industry Co.,Ltd.,Nation Engineering Research Center for Agrochemicals,Changsha 410014,China;Hunan Province Key Laboratory for Agrochemicals,Changsha 410014,China;Hunan Haili Changde Pesticide&Chemicals Co.,Ltd.,Changde 415001,China)

机构地区：[1]湖南化工研究院有限公司,国家农药创制工程技术研究中心,湖南长沙410014 [2]农用化学品湖南省重点实验室,湖南长沙410014 [3]湖南海利常德农药化工有限公司,湖南常德415001

出　　处：《精细化工中间体》2020年第2期22-25,共4页Fine Chemical Intermediates

基　　金：国家重点研发计划项目(2017YFB0307200)。

摘　　要：以氯代特戊酰氯、盐酸羟胺和邻氯苄氯为主要原料,经酰化反应、成环反应、缩合反应得到粗品异噁草酮,再经氯化氢气体处理和异丙醇/石油醚重结晶,制备得到高品质异噁草酮原药,含量超过98.0%。此方法具有工艺条件温和、易操作、含量高等优点,适合大规模工业化生产。The crude product of clomazone was synthesized using chlorotervaloyl chloride, hydroxylamine hydrochloride and 2-chlorobenzyl chloride as raw materials through a series ractions including oximation, cyclization and condensation. Clomazone with a purity of more than 98.0% was obtained by purifying the crude product with HCl gas and recrystallization from iso-propyl alcohol/petroleum ether. This method was suitable for large-scale industrial production with many advantages such as mild reaction conditions, simple operation, high quality. etc.

关 键 词：异噁草酮 氯代特戊酰氯 高品质 重结晶 

分 类 号：S482.4[农业科学—农药学]