体检人群低密度脂蛋白胆固醇计算公式的研究  

Study on the calculation formula of LDL-C in physical examination population

作　　者：蔡红军[1] 韩静[2] 叶军[2] 陈昱星 朱文凯 CAI Hongjun;HAN Jing;YE Jun;CHEN Yuxing;ZHU Wenkai(Tai Zhou Blood Center,Taizhou,Jiangsu 225300,China;Medical Transformation Center,Tai Zhou People′s Hospital,Taizhou,Jiangsu 225300,China;Mathematics Group,Tai Zhou No.2 Middle School,Taizhou,Jiangsu 225300,China;Department of Reproduction,Tai Zhou People′s Hospital,Taizhou,Jiangsu 225300,China)

机构地区：[1]江苏省泰州市中心血站,江苏泰州225300 [2]江苏省泰州市人民医院医学转化中心,江苏泰州225300 [3]江苏省泰州市第二中学数学组,江苏泰州225300 [4]江苏省泰州市人民医院生殖科,江苏泰州225300

出　　处：《检验医学与临床》2020年第14期1988-1991,共4页Laboratory Medicine and Clinic

摘　　要：目的寻找最适合中国人群低密度脂蛋白胆固醇(LDL-C)的计算方法。方法将泰州市人民医院的体检者和泰州市中心血站参加免疫体检的献血者共490例纳入研究。对不同公式的计算值和实测值之间的相关性进行分析;对不同公式的计算值与实测值的差值及差值百分比进行计算和比较;评价各公式计算值与实测值的一致性;分析随着TG、HDL-C的增高或降低,4种公式的使用效果。结果4种LDL-C计算方法的结果与实测LDL-C值均有良好的相关性:相关性由高到低依次为M公式(r=0.980)、P公式(r=0.961)、F公式(r=0.940)、H公式(r=0.895)。M公式计算结果与实测值的差值和差值百分比均低于其他3种公式(P<0.001)。M公式计算值与实测值的一致性最佳;M公式差值百分比低于5%和10%的体检者所占比例最高。随着TG、HDL-C水平的增加,M公式的差值和差值百分比变化均为最小。结论M公式为最适合中国人群的LDL-C计算公式。Objective To find the best method for calculating low-density lipoprotein cholesterol(LDL-C)in Chinese population.Methods A total of 490 health checkup examinees were enrolled in the study,including people from Tai Zhou People′s Hospital and blood donors receiving free physical examination from Tai Zhou blood center.Analyze the correlation between the calculated value and the measured value;compare the difference and the percentage of difference among different formulas;evaluate the consistency between the calculated value and the measured value for each formula;with the increase of TG and HDL-C concentration,the applicability of the 4 formulas were analyzed.Results All of the four LDL-C calculation methods correlated well with the measurement method:the correlation from high to low were M formula(r=0.980),P formula(r=0.961),F formula(r=0.940),H formula(r=0.895).The difference and percentage of difference between the calculated results of Formula M and the measured values were lower than those of the other three formulas(P<0.001).The consistency between the calculated value of M formula and the measured value is the best;the proportion of the people whose difference percentage of M formula is lower than 5%and 10%is the highest.With the increase of TG and HDL-C,the difference and percentage of difference of M formula are the smallest.Conclusion M formula is the most suitable LDL-C formula for Chinese people.

关 键 词：低密度脂蛋白胆固醇 计算公式 体检人群 

分 类 号：R446.1[医药卫生—诊断学]