肠道菌群对肠道神经-内分泌-免疫系统的影响及其病理生理意义  

Effects and pathophysiological significance of intestinal flora on the enteric neuroendocrine-immune system

作　　者：徐翰南 蔡征真 王云[1] 吴多尔 戎伟芳 张国花 XU Han-Nan;CAI Zheng-Zhen;WANG Yun;WU Duo-Er;RONG Wei-Fang;ZHANG Guo-Hua(Department of Anatomy and Physiology,Basic Medical School,Shanghai Jiao Tong University,Shanghai 200025,China)

机构地区：[1]上海交通大学基础医学院解剖学与生理学系,上海200025

出　　处：《生理学报》2020年第3期347-360,共14页Acta Physiologica Sinica

基　　金：Research from the corresponding author’s laboratory was supported by the National Natural Science Foundation of China(No.81770533).

摘　　要：神经、内分泌、免疫系统之间的相互作用使胃肠道得以对其吸收的各种食物、遭遇的各种病原体以及在此寄宿的多种微生物作出反应,维持机体的稳态。然而,肠道菌群紊乱可能会通过影响肠神经系统(enteric nervous system, ENS)、肠内分泌细胞和免疫细胞的活动引起或加重疾病的发生和发展。本文将围绕肠道菌群对肠道神经-内分泌-免疫系统的影响及其病理生理意义作一综述。Interactions among the nervous,the endocrine and the immune systems enable the gut to respond to the dietary products,pathogens and microbiota,which maintains the homeostasis of the body.However,dysbiosis may induce or aggravate the gastrointestinal(GI)and extra-GI diseases through changing the activities of enteric nervous system(ENS),enteroendocrine cells and enteric immune cells.Here we review recent advances in the understandings on how intestinal flora may impact the enteric neuro-endocrine-immune system in the gut,thereby contributing to the regulation of pathophysiological processes.

关 键 词：肠道菌群 肠神经系统 肠内分泌细胞 肠免疫细胞 

分 类 号：R333[医药卫生—人体生理学] R338[医药卫生—基础医学]