新型冠状病毒肺炎病例病程影响因素及实验室检测情况分析  

Analysis on factors influencing duration of Corona Virus Disease 2019 and laboratory detection results

作　　者：刘娜[1] 刘成[1] 夏瑜[2] 谭亚运[1] 张钧[3] 陈立凌[1] 徐娟 郑本锋[1] 栾琳[1] LIU Na;LIU Cheng;XIA Yu;TAN Ya-yun;ZHANG Jun;CHEN Li-ling;XU Juan;ZHENG Ben-feng;LUAN Lin(Department of Infectious Diseases Prevention and Control,Suzhou Center for Disease Control and Prevention,Suzhou Jiangsu,215004,China;Clinical Laboratory,Suzhou Center for Disease Control and Prevention,Suzhou Jiangsu,215004,China;Central Office,Suzhou Center for Disease Control and Prevention,Suzhou Jiangsu,215004,China)

机构地区：[1]苏州市疾病预防控制中心传染病防制科,江苏苏州215004 [2]苏州市疾病预防控制中心检验科,江苏苏州215004 [3]苏州市疾病预防控制中心中心办公室,江苏苏州215004

出　　处：《职业与健康》2020年第10期1349-1351,1354,共4页Occupation and Health

基　　金：江苏省青年医学重点人才项目(QNRC2016230);苏州市医学重点学科(Szxk201516);姑苏卫生人才计划(GSWS2019024);2020年苏州市“新型冠状病毒感染应急防治”科技专项项目。

摘　　要：目的分析苏州市新型冠状病毒肺炎(COVID-19)已出院确诊病例疾病病程及实验室检测情况。方法根据国家疾病预防控制信息系统报告的病例个案信息,结合流行病学调查报告信息对截止2020年2月26日苏州市59例已出院确诊病例的病程天数的影响因素进行logistic回归分析;对病例在医疗机构采集的病原学标本的实验室检测结果进行描述分析。结果年龄≥43岁或有湖北省等疫区旅居史的病例病程较长(≥23 d)的可能性分别是年龄<43岁或无外出史密切接触发病者的4.05倍(P<0.05,95%CI为1.23~13.36)和5.55倍(P<0.05,95%CI为1.14~27.15);病程11天内的病原学标本检出以阳性结果为主,第12天后以阴性结果为主。结论疫区旅居史和年龄偏大是COVID-19病程的主要影响因素,提示密切接触者的及时隔离观察和加强对中老年人群的疾病防控健康宣教非常重要。从实验室检测结果看,COVID-19病例治疗效果可能从病程的12天开始显现。Objective To analyze the duration of disease and laboratory detection results of discharged patients with Corona Virus Disease 2019(COVID-19)in Suzhou City.Methods Logistic regression analysis was conducted on the factors influencing the duration of illness of 59 discharged patients in Suzhou City based on the case information reported by China Information System for Disease Control and Prevention and the epidemiological investigation information.The results of laboratory detection on pathogenic specimens collected from medical institutions were analyzed.Results Compared with those people aged less than 43 years old or not with a history of sojourn in Hubei or other epidemic areas but having close contact with confirmed cases,the probability for COVID-19 of longer duration(≥23 days)in those people aged over 43 years old or with a history of sojourn in Hubei Province or other epidemic areas would be 4.05 times(P<0.05,95%CI:1.23-13.36)and 5.55 times(P<0.05,95%CI:1.14-27.15).In the duration of the disease for 11 days,the most positive results were found,while from the 12 th day on,negative results were predominant.Conclusion The history of sojourn in epidemic area and the older age are the significant factors influencing the course of COVID-19,so it is very important to isolate and observe those closing-contact with confirmed cases in time and strengthen the health education of COVID-19 in the middle-aged and elderly.The treatment may be begin to improve from the 12th day of the duration of COVID-19,depending on the results of laboratory detection.

关 键 词：新型冠状病毒肺炎 新型冠状病毒 疾病病程 实验室检测 

分 类 号：R181.81[医药卫生—流行病学]