生物化学多项指标检测诊断肝胆汁淤积性肝硬化的价值探析  

The value of multiple biochemical indexes in the diagnosis of hepatic cholestatic cirrhosis

作　　者：王兴善[1] 于小汇[1] 罗迪[1] Wang Xingshan;Yu Xiaohui;Luo Di(Department of Clinical Laboratory,The Second People's Hospital of Dalian City,Liaoning Province,Dalian,Liaoning,116011,China)

机构地区：[1]辽宁省大连市第二人民医院检验科,辽宁大连116011

出　　处：《当代医学》2020年第21期101-103,共3页Contemporary Medicine

摘　　要：目的探析在肝胆汁淤积性肝硬化诊断中生物化学多项指标检测的价值。方法选取2017年8月至2019年1月在本院确诊为肝胆汁淤积性肝硬化患者46例为实验组,并选取同期在本院进行健康体检者46名为对比组,以全自动生化分析仪分析测定两组总胆红素、碱性磷酸酶、丙氨酸转氨酶等多项生化指标,并比较检测结果阳性检出率。结果实验组总胆红素、碱性磷酸酶、丙氨酸转氨酶、谷草转氨酶、γ-谷氨酰转肽酶、直接胆红素高于对比组(P<0.05);实验组总蛋白、胆碱酯酶、白蛋白低于对比组(P<0.05);实验组总胆红素、碱性磷酸酶、丙氨酸转氨酶等多项生化指标阳性检出率均高于对比组(P<0.05)。结论肝胆汁淤积性肝硬化患者多项生化指标检测与健康人群比较差异有统计学意义,有助于诊断肝胆汁淤积性肝硬化的准确性。Objective To explore the value of biochemical multiple indexes in the diagnosis of hepatic cholestatic cirrhosis. Methods 46 patients with liver cholestasis cirrhosis diagnosed in our hospital from August 2017 to January 2019 were selected as the experimental group, and 46 medical examinees who underwent health testing in our hospital during the same period were selected as the control group. Analyzed and measured the total bilirubin, alkaline phosphatase, alanine aminotransferase and other biochemical indicators of the two groups of patients with automatic biochemical analyzer, and compared the positive detection rate of the test results. Results The corresponding values of total bilirubin, alkaline phosphatase, alanine transaminase, glutamine transaminase, gamma-glutamyl transpeptidase and direct bilirubin in the experimental group were higher than those in the control group(P<0.05). The corresponding values of total protein, cholinesterase and albumin in the experimental group were lower than those in the control group(P<0.05). The positive detection rate of total bilirubin, alkaline phosphatase, alanine transaminase and other biochemical indicators in the experimental group was higher than that in the control group(P<0.05). Conclusion There was significant difference in the biochemical indexes in the examination of patients with hepatic biliary cirrhosis compared with healthy people, which is helpful to the accuracy of the diagnosis of hepatic biliary cirrhosis.

关 键 词：生化指标 肝胆汁淤积性肝硬化 诊断 

分 类 号：R446.1[医药卫生—诊断学] R575.2[医药卫生—临床医学]