老年女性风湿免疫病患者骨质疏松的影响因素临床分析  

Clinical analysis of influencing factors of osteoporosis in elderly female patients with rheumatic immune disease

作　　者：张嵩 陈琳洁[1] 郭文静[1] 谢长好[1] ZHANG Song;CHEN Linjie;GUO Wenjing;XIE Changhao(Department of Rheumatology and Immunology,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233030,China)

机构地区：[1]蚌埠医学院第一附属医院风湿免疫科,安徽蚌埠233030

出　　处：《沈阳医学院学报》2020年第4期325-328,共4页Journal of Shenyang Medical College

摘　　要：目的:探讨生育、运动、饮食对老年女性风湿免疫病患者骨质疏松的影响,寻找防治骨质疏松的方法。方法:回顾性分析2013年1月至2014年6月我院门诊及住院且资料完整的512例老年女性风湿免疫病患者的临床资料,包括患者骨密度、年龄、身高、体重、运动、绝经年龄、怀孕次数、分娩次数、饮用牛奶、日照等。根据骨密度将患者分为骨质疏松组与非骨质疏松组,对比2组的临床资料。结果:骨质疏松组与非骨质疏松组患者的身高、体重、年龄、运动、分娩次数、饮食因素比较,差异均有统计学意义(P<0.05)。老年女性风湿免疫病患者的股骨颈骨密度、全髋骨密度、腰椎骨密度均与身高、体重呈正相关(r身高=0.120、0.124、0.150,r体重=0.131、0.149、0.110),而与年龄、分娩次数呈负相关(r年龄=-0.218、-0.187、-0.23,r分娩次数=-0.139、-0.122、-0.195);全髋骨密度、腰椎骨密度与运动呈正相关(r=0.10、0.12);全髋骨密度与日照时间呈正相关(r=0.10)(P<0.05)。逐步二项Logistic回归分析发现,年龄、分娩次数是老年女性风湿免疫病患者骨质疏松的危险因素,而体重、运动、饮用牛奶是患者骨质疏松的保护因素。结论:年龄大、分娩次数多、体重减轻是老年女性风湿免疫病患者骨质疏松的危险因素,运动、每天饮用牛奶可以减少其发生。Objective:To investigate the effects of fertility,exercise and diet on osteoporosis(OP)in elderly female patients with rheumatic immune disease,in order to provide evidence for the prevention and treatment of OP.Methods:From Jan 2013 to Jun 2014,clinical data of 512 outpatient and inpatient elderly female patients with rheumatic immune disease were retrospectively analyzed,including bone mineral density(BMD),age,height,weight,exercise,age of menopause,number of pregnancies,number of deliveries,milk intake,sunshine etc.They were divided into 2 groups according to BMD,and the clinical data were compared.Results:There were statistically significant differences in height,weight,age,exercise,number of deliveries and diet between the OP group and the non-OP group(P<0.05).The femoral neck BMD,total hip BMD,lumbar spine BMD were positively correlated with height and weight(rheight=0.120,0.124,0.150,rweight=0.131,0.149,0.110),and negatively correlated with age and number of deliveries(rage=-0.218,-0.187,-0.23,rdelivery=-0.139,-0.122,-0.195).The total hip BMD,lumbar spine BMD were positively correlated with exercise(r=0.10,0.12).The total hip BMD was positively correlated with sunshine(r=0.10)(P<0.05).The stepwise binary logistic regression analysis showed that age and number of deliveries were risk factors for osteoporosis in elderly female patients with rheumatic immune disease,while weight,exercise and milk intake were protective factors.Conclusion:Older age,multiple deliveries and weight loss are risk factors for osteoporosis in elderly women with rheumatic immune disease,exercise and daily milk intake can reduce the risk of osteoporosis.

关 键 词：老年女性 骨密度 分娩次数 运动 牛奶 

分 类 号：R683[医药卫生—骨科学]