PGE2/EP信号通路在肺部疾病中作用的研究进展  

Research progress on role of prostaglandin E2/prostacyclin receptor signaling pathway in lung diseases

作　　者：陈建安 李德富[1] 袁良 易高[1] Chen Jian′an;Li Defu;Yuan Liang;Yi Gao(Department of Respiratory Medicine,the Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou 510700,China)

机构地区：[1]广州医科大学附属第五医院呼吸内科,510700

出　　处：《国际呼吸杂志》2020年第12期944-949,共6页International Journal of Respiration

基　　金：国家自然科学基金(81873419);广东省自然科学基金(2018A030313587)。

摘　　要：前列腺素E2(PGE2)由花生四烯酸代谢而成,含有4个碳-碳双键,为高级不饱和脂肪酸。PGE2能在多种细胞中产生并作用于不同类型的前列环素受体(EP),在调节心血管系统及维持水盐内环境稳态中起重要作用。近年来,越来越多的研究表明PGE2/EP信号通路在慢性阻塞性肺疾病中发挥着重要作用,且其在哮喘、肺癌以及急性肺损伤中可能均起到一定的作用。本文将对PGE2/EP信号通路在各种肺部疾病中的作用进行综述。Prostaglandin E2(PGE2)is metabolized by arachidonic acid and contains four carbon-carbon double bonds,which is high-grade unsaturated fatty acid.PGE2 can be produced in a variety of cells and acts on different types of prostacyclin receptors(EP),playing an important role in regulating the cardiovascular system and maintaining the homeostasis of water and salt.In recent years,more and more studies have shown that PGE2/EP signaling pathway plays an important role in chronic obstructive pulmonary disease,and it may play a role in asthma,lung cancer and acute lung injury.This article reviews the role of PGE2/EP signaling pathway in various lung diseases.

关 键 词：前列腺素E2/前列腺素E受体信号通路 肺肿瘤 急性肺损伤 肺疾病 慢性阻塞性 过敏性哮喘 

分 类 号：R563[医药卫生—呼吸系统]