胰高血糖素样肽-1受体PET/CT定位诊断胰岛素瘤的技术规范  

Procedure Guideline of Glucagon-like Peptide-1 Receptor Positron Emission Tomography/Computed Tomography in Localizing Insulinoma

作　　者：罗亚平[1,2] 李方 于淼[3] 邢小平 张太平[4] 赵玉沛[4] LUO Ya-ping;LI Fang;YU Miao;XING Xiao-ping;ZHANG Tai-ping;ZHAO Yu-pei(Department of Nuclear Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine,Bejjing 100730,China;Department of Endocrinology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of General Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China 2 Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine,Bejjing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院核医学科,北京100730 [2]核医学分子靶向诊疗北京市重点实验室,北京100730 [3]中国医学科学院,北京协和医学院,北京协和医院内分泌科,北京100730 [4]中国医学科学院,北京协和医学院,北京协和医院基本外科,北京100730

出　　处：《协和医学杂志》2020年第4期486-491,共6页Medical Journal of Peking Union Medical College Hospital

基　　金：国家自然科学基金(81501515);公益性行业科研专项(201402001)。

摘　　要：胰岛素瘤的诊断和手术治疗依赖于准确的影像学检查定位。以胰腺β细胞为靶点的胰高血糖素样肽-1受体(glucagon-like peptide-1 receptor,GLP-1R)是近年来胰岛素瘤影像研究中的亮点,推荐临床推广使用68Ga-exendin-4进行GLP-1R正电子发射断层显像/计算机体层成像(positron emission tomography/computed tomography,PET/CT)来定位诊断胰岛素瘤。本文介绍GLP-1R显像在胰岛素瘤中的应用概况,并以68Ga-exendin-4 GLP-1R PET/CT显像为例,介绍该技术的操作规范,以期为临床提供借鉴。The diagnosis and surgical treatment of insulinoma is dependent on accurate localization with imaging modalities.Glucagon-like peptide-1 receptor(GLP-1 R)imaging that targets pancreaticβcells has been highlighted for detecting insulinomas in recent years.Since the high sensitivity and specificity(se.99%,sp.100%)of GLP-1 R imaging in localizing insulinoma,GLP-1 R positron emission tomography/computed tomography(PET/CT)with 68Ga-exendin-4 is recommended to be introduced into clinical practice.This paper introduced the application of GLP-1 R imaging in insulinoma,and took the GLP-1 R PET/CT with 68Ga-exendin-4 as an example to elaborate the operation standard of this technique,aiming to provide a reference for clinical practice.

关 键 词：胰高血糖素样肽-1受体 68Ga-exendin-4 胰岛素瘤 技术 

分 类 号：R587[医药卫生—内分泌] R445[医药卫生—内科学]