事件相关电位P300在意识障碍预后评估中的应用进展  

Advance in P300Wave for Prognosis of Consciousness Disorders(review)

作　　者：孙晓琴 冯英[1,2] 肖农 SUN Xiao-qin;FENG Ying;XIAO Nong(Department of Rehabilitation,Children's Hospital of Chongqing Medical University,Chongqing 400014,China;Ministry of Education Key Laboratory of Child Development and Disorders,National Clinical Research Center for Child Health and Disorders,China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院康复科,重庆市400014 [2]儿童发育疾病研究教育部重点实脸室,国家儿童健康与疾病临床医学研究中心,儿童发育重大疾病国家国际科技合作基地,重庆市400014

出　　处：《中国康复理论与实践》2020年第7期784-787,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：重庆市科卫联合项目(No.2018ZDXM029)。

摘　　要：越来越多的重度脑损伤患者伴有严重意识障碍,准确客观地评估他们的脑功能及预后亟待解决。在意识障碍患者中,事件相关电位P300潜伏期延长,振幅降低,可反映患者的残余认知功能;P300振幅和潜伏期的动态变化可用于判断认知功能的恢复程度;特殊的刺激形式产生的P300可能对于区分植物状态和最小意识状态有一定价值。Severe brain-injured patients would suffer severe disorders of consciousness for a long time.It is needed to prognose their brain function and outcomes.P300 wave of event-related potentials may feature as long latency and short amplitude in disorders of consciousness,which respond to the residual cognitive function.The dynamic changes of P300 wave amplitude and latency can be used to determine the recovery of cognitive function.The P300 waves induced by special stimulus may help to differentiate the vegetative state from the minimally conscious state.

关 键 词：事件相关电位 P300 意识障碍 综述 

分 类 号：R651.1[医药卫生—外科学]