纤维基介孔SiO2药物载体的构建及其释药性能  

Construction and drug release properties of fiber-based mesoporous SiO2 drug carrier

作　　者：段红梅 汪希铭 黄子欣 高晶[1] 王璐[1] DUAN Hongmei;WANG Ximing;HUANG Zixin;GAO Jing;WANG Lu(College of Textiles, Donghua University, Shanghai 201620, China)

机构地区：[1]东华大学纺织学院,上海201620

出　　处：《纺织学报》2020年第7期15-22,共8页Journal of Textile Research

基　　金：国家卫生计生委重大疾病防治科技行动计划专项(2017ZX01001-S22)。

摘　　要：为研究纤维基载药介孔SiO2纳米粒子的释药性能,采用溶胶-凝胶法制备介孔SiO2,并采用静电纺丝技术制备了负载介孔SiO2的聚己内酯(PCL)纤维膜,在介孔SiO2纳米粒子中装载抗菌药物盐酸环丙沙星,于酸性条件下分别探讨了盐酸环丙沙星在纳米粒子和复合纤维膜中的释放性能及释放机制,并对2种药物释放模型进行动力学研究。结果表明:介孔SiO2纳米粒子的成型受pH值影响较大,在可成型范围内,随着pH值的增大,纳米粒子的粒径逐渐增大;随着介孔SiO2比例的增加,PCL复合纤维的细度逐渐下降;盐酸环丙沙星在单独纳米粒子和复合纤维膜中的释放都具有初始释放速率大,后期释放缓慢的特点,12 h内在2种载体中的累积释放率分别可达到55.51%和16.53%;扩散是药物在2种载体中释放的主要机制。In order to study the drug releasing performance of fiber-based mesoporous SiO2,mesoporous SiO2 nanoparticles was prepared using sol-gel method,and the polycaprolactone(PCL)fiber membranes loaded with mesoporous SiO2 nanoparticles were prepared by electrospinning.The antibacterial drug ciprofloxacin hydrochloride was loaded into mesoporous SiO2 nanoparticles,and the releasing properties and releasing mechanism of ciprofloxacin hydrochloride in individual nanoparticles and composite fiber membranes were investigated under acidic conditions.The results show that the formation of mesoporous SiO2 nanoparticles is greatly affected by pH value.Within the moldable range,the particle size of the nanoparticles increases with increasing pH value.As the proportion of mesoporous SiO2 nanoparticles increases,the fineness of PCL composite fibers gradually decreases.The release of ciprofloxacin hydrochloride in individual nanoparticles and composite fiber membranes has a large initial release rate and a slow release in the later stage,the cumulative release rate in the two carriers within 12 h reaches 55.51%and 16.53%,respectively.The results of kinetic studies on the two drug release models indicate that diffusion is the main mechanism of drug release.

关 键 词：介孔二氧化硅 纳米纤维膜 盐酸环丙沙星 载药 药物释放 

分 类 号：TS101.4[轻工技术与工程—纺织工程]