腹腔镜手术联合诺雷得治疗卵巢子宫内膜异位症的效果观察  

Observation of effect of laparoscopic surgery combined with Zoladex on the treatment of ovarian endometriosis

作　　者：刘丽娜 LIU Li-na(Yangdong District People’s Hospital,Yangjiang 529500,China)

机构地区：[1]阳东区人民医院,529500

出　　处：《中国现代药物应用》2020年第14期14-16,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨腹腔镜手术联合醋酸戈舍瑞林缓释植入剂(商品名:诺雷得)治疗卵巢子宫内膜异位症的临床效果。方法 82例卵巢子宫内膜异位症患者,随机分为对照组和试验组,每组41例。对照组患者在月经干净后予以腹腔镜手术,试验组在对照组基础上联合诺雷得治疗。比较两组患者临床疗效、复发率、妊娠率、恢复月经时间、不良反应发生情况以及治疗前与治疗6个月后促黄体生成素(LH)、卵泡雌激素(FSH)、雌二醇(E2)、糖类抗原125(CA125)水平。结果试验组治疗总有效率97.56%高于对照组的80.49%,差异具有统计学意义(P<0.05)。治疗6个月后,两组患者LH、FSH、E2、CA125水平均低于治疗前,且试验组患者的LH(2.36±0.84)U/L、FSH(2.52±1.16)U/L、E2(102.15±32.05)ng/L、CA125(20.67±1.53)U/ml均低于对照组的(3.29±1.24)U/L、(3.37±1.19)U/L、(157.49±33.29)ng/L、(31.29±2.47)U/ml,差异均具有统计学意义(P<0.05)。试验组的复发率2.44%低于对照组的19.51%,妊娠率97.56%高于对照组的73.17%,恢复月经时间(28.65±4.39)d短于对照组的(39.52±5.41)d,不良反应发生率7.32%低于对照组的29.27%,差异均具有统计学意义(P<0.05)。结论腹腔镜手术联合诺雷得治疗卵巢子宫内膜异位症具有较大的有效性,不仅能够降低LH、FSH、E2、CA125水平、复发率与不良反应发生率,同时能够提升临床治疗总有效率与妊娠率,缩短恢复月经时间。Objective To discuss the clinical effect of laparoscopic surgery combined with goserelin acetate sustained-release depot(trade name: Zoladex) on the treatment of ovarian endometriosis. Methods A total of 82 patients with ovarian endometriosis were randomly divided into control group and experimental group, with 41 cases in each group. The control group was treated by laparoscopic surgery after menstruation was clean, and the experimental group was treated by Zoladex on the basis of the control group. The clinical efficacy, recurrence rate, pregnancy rate, time of menstruation recovery and occurrence of adverse reactions, the levels of luteinizing hormone(LH), follicle stimulating hormone(FSH), estradiol(E2), carbohydrate antigen 125(CA125) before treatment and 6 months after treatment were compared between the two groups. Results The total effective rate of treatment 97.56% of the experimental group was higher than that of the control group 80.49%, and the difference was statistically significant(P<0.05). 6 months after treatment, the levels of LH, FSH, E2 and CA125 was lower than those before treatment, and the levels of LH, FSH, E2 and CA125 of the experimental group were(2.36±0.84) U/L,(2.52±1.16) U/L,(102.15±32.05) ng/L and(20.67±1.53)U/ml, which were all lower than those of the control group(3.29±1.24) U/L,(3.37±1.19) U/L,(157.49±33.29) ng/L and(31.29±2.47) U/ml, and the difference was statistically significant(P<0.05). The recurrence rate 2.44% of the experimental group was lower than that of the control group 19.51%, pregnancy rate 97.56% was higher than that of the control group 73.17%, time of menstruation recovery(28.65±4.39) d was shorter than that of the control group(39.52±5.41) d and occurrence of adverse reactions 7.32% was lower than that of the control group 29.27%, and the difference was statistically significant(P<0.05). Conclusion Laparoscopic surgery combined with Zoladex is more effective in the treatment of ovarian endometriosis. It can not only reduce the level of LH, FSH, E2, CA

关 键 词：腹腔镜手术 诺雷得 卵巢子宫内膜异位症 临床效果 

分 类 号：R711.71[医药卫生—妇产科学]