正常妊娠妇女不同孕期血浆D-二聚体变化及其临床意义探讨  

Investigation on changes of D-dimer during different pregnant periods in normal pregnant women and their clinical significance

作　　者：辜少玲 郑浩 梁绮华 曾兰兰 汪道文 黄镇华 GU Shaoling;ZHENG Hao;LIANG Qihua;ZENG Lanlan;WANG Daowen;HUANG Zhenhua(Department of Clinical Laboratory,Guangzhou Women and Children's Medical Center,Guangzhou,Guangdong 510623,China)

机构地区：[1]广州市妇女儿童医疗中心检验科,广东广州510623

出　　处：《国际检验医学杂志》2020年第S01期141-143,共3页International Journal of Laboratory Medicine

摘　　要：目的研究正常妊娠妇女不同时期血浆D-二聚体的变化情况,并探讨其在不同孕期中的临床意义。方法选取2018年1月至2019年4月广州市妇女儿童医疗中心不同孕期健康孕妇1160例及同期在本院体检中心体检的350例正常育龄期非孕妇女作为对照组,试验组按年龄分为18~<30、30~<35、35~<40、40~45岁共4个年龄段。所有受试对象采集枸橼酸钠抗凝静脉血2.0 mL,采用STA-R Evolution全自动血凝仪检测其血浆D-二聚体浓度,对检测结果进行统计分析。结果孕期各组与对照组比较,各年龄组D-二聚体浓度均显著升高(P<0.05)。孕期各组之间比较,孕晚期各年龄组D-二聚体浓度较孕中期均显著升高(P<0.05);孕中期除35~<40岁年龄组,其他各年龄组D-二聚体浓度较孕早期亦均显著升高(P<0.05)。而各孕期组内D-二聚体浓度比较,差异均无统计学意义(P>0.05)。结论妊娠妇女凝血功能增强,血浆处于高凝状态,且随着妊娠进展而加强,因此定期监测凝血功能,对预防产科并发症有重要意义,并且有必要建立与孕妇各妊娠阶段相适应的临床参考值范围。Objective To study the change of D-dimer of pregnant women in different periods and to explore the clinical significance during different pregnancy.Methods From January 2018 to April 2019,a totally of 1160 healthy pregnant women in Guangzhou Women and Children's Medical Center were choosen as experience group,and another 350 non-pregnant women in the physical examination center were choosen as the control group.All cases were divided into four age groups:18-<30,30-<35,35-<40,and 40-45.All cases were treated with sodium citrate anticoagulated venous blood 2.0 ml and the concentration of D-dimer in plasma was measured by STA-R Evolution,and the results were analyzed statistically.Results Compared with the control group,the concentration of D-dimer in each age group increased significantly(P<0.05).The concentration of D-dimer in each age group in the third trimester was significantly higher than that in the second trimester(P<0.05);in the second trimester,except for the 35-40 age group,the concentration of D-dimer in other age groups was also significantly higher than that in the first trimester(P<0.05).However,there was no significant difference in the concentration of D-dimer among the pregnant groups(P>0.05).Conclusion The coagulation function of pregnant women is strong,the plasma is in hypercoagulable state,and it will be strengthened with the progress of pregnancy.Therefore,regular monitoring of coagulation function is of great significance for the prevention of obstetric complications,and it is necessary to establish the clinical reference value range suitable for each pregnancy stage of pregnant women.

关 键 词：D-二聚体 妊娠 凝血 

分 类 号：R71[医药卫生—妇产科学]