广州地区哮喘及变应性鼻炎和湿疹儿童血清特异性过敏原IgE的对比分析  

Serum specific allergen IgE in children with asthma,allergic rhinitis,and eczema in Guangzhou

作　　者：陈广道 吴子谕[2] 刘运可 王亚曙 Chen Guangdao;Wu Ziyu;Liu Yunke;Wang Yashu(Department of Pediatrics,Guangdong Women and Children Hospital,Guangzhou 511442,China;Department of Ultrasound,Guangdong Women and Children Hospital,Guangzhou 511442,China)

机构地区：[1]广东省妇幼保健院儿科,广州511442 [2]广东省妇幼保健院B超科,广州511442

出　　处：《国际医药卫生导报》2020年第14期2104-2107,共4页International Medicine and Health Guidance News

摘　　要：目的了解过敏原特异性IgE在儿童不同过敏性疾病中的分布情况,为制定环境干预措施提供依据。方法采用酶联免疫法检测哮喘(101例)、变应性鼻炎(250例)和湿疹(162例)患儿血清特异性过敏原IgE,同时对比3种过敏性疾病的特异性过敏原IgE分布情况。结果三组的总IgE水平及阳性率比较,差异均无统计学意义(均P>0.05);吸入性过敏原阳性率高于食入性过敏原,屋尘螨/粉尘螨是首位过敏原;哮喘组和鼻炎组的屋尘、屋尘螨/粉尘螨的特异性IgE水平及阳性率均显著高于湿疹组,差异均有统计学意义(均P<0.05);但哮喘和变应性鼻炎儿童比较,差异均无统计学意义(均P>0.05);三组的食入性过敏原特异性IgE的水平及阳性率比较,差异均无统计学意义(均P>0.05)。结论儿童哮喘、变应性鼻炎和湿疹儿童主要对吸入性过敏原致敏,屋尘螨/粉尘螨是首位过敏原。哮喘和变应性鼻炎儿童的过敏原构成一致,哮喘或变应性鼻炎与湿疹儿童的过敏原构成存在显著差异。Objective To evaluate allergen IgE antibody distribution in children with different allergic diseases,and to provide references for clinical intervention.Methods 101 children with asthma,250 with allergic rhinitis,and 162 with eczema were enrolled.ELISA was performed to detect the serological specific allergen IgE in all the children.The allergen IgE antibody distributions in the 3 groups were analyzed.Results There were no statistical differences in the total IgE level and positive rate between the three groups.The positive rates of inhaled allergens were higher than those of ingested allergens.Dust mite was the most common allergen.The specific IgE levels and positive rates of dust mite in the asthma group and rhinitis group were significantly higher than those in the eczema group,but there were no statistical differences between those of the children with asthma and those of those with allergic rhinitis.There were no statistical differences in the levels and positive rates of ingested allergen specific IgE between the three groups.Conclusions Children with asthma,allergic rhinitis,or eczema are mainly sensitized to inhaled allergens.Dust mite is the most common allergen.Children with asthma and allergic rhinitis have similar allergen composition.There is a significant difference in the composition of allergens between children with asthma,allergic rhinitis,and eczema.

关 键 词：儿童 哮喘 变应性鼻炎 湿疹 血清特异性过敏原IgE 

分 类 号：R725.6[医药卫生—儿科] R765.21[医药卫生—临床医学] R758.23