右美托咪定联合七氟醚用于子痫前期患者剖宫产麻醉中的效果  被引量:10

Effects of dexmedetomidine combined with sevoflurane on cesarean section anesthesia in patients with preeclampsia

在线阅读下载全文

作  者:侯晓飞[1] HOU Xiaofei(Department of Anesthesiology,the Second People′s Hospital of Nanyang City,Nanyang 473012,China)

机构地区:[1]南阳市第二人民医院麻醉科,南阳473012

出  处:《西北药学杂志》2020年第4期577-581,共5页Northwest Pharmaceutical Journal

摘  要:目的探究右美托咪定联合七氟醚用于子痫前期患者剖宫产麻醉中的效果。方法回顾性分析我院经七氟醚麻醉(对照组)及经右美托咪定联合七氟醚麻醉(观察组)行剖宫产分娩的子痫前期患者各62例临床资料。比较2组给药前(t0)、麻醉诱导后(t1)、胎儿娩出时(t2)和拔管时(t3)的生命体征指标[平均动脉压(MAP)、心率(HR)和血氧饱和度(SpO2)]和术前及术后即刻应激反应[皮质醇(Cor)和去甲肾上腺素(NE)]差异,并记录2组t1、t2和t3时麻醉镇静效果(Richmond镇静躁动评分)、围手术期不良反应(寒颤、消化道反应、低血压和心动过缓)及新生儿出生后1和5 min Apgar评分情况。结果2组各时间点MAP和HR变化情况均为t0>t3>t2>t1(P<0.05),t0和t1时,2组MAP和HR比较,差异无统计学意义(P>0.05),t2和t3时,观察组MAP和HR均低于对照组,差异有统计学意义(P<0.05),2组组内与组间各时间点SpO2比较,差异均无统计学意义(P>0.05)。术后即刻,2组血浆Cor和NE水平均较术前升高,差异有统计学意义(P<0.05),且对照组高于观察组,差异有统计学意义(P<0.05)。t1时,2组Richmond评分比较差异无统计学意义(P>0.05);t2和t3时,观察组Richmond评分均低于对照组,差异有统计计学意义(P<0.05)。2组围手术期不良反应及新生儿出生后1和5 min Apgar评分比较差异无统计学意义(P>0.05)。结论右美托咪定联合七氟醚用于子痫前期患者剖宫产麻醉中镇静效果显著,能减小患者术中生命体征波动,减轻手术应激反应,对孕母及新生儿不良影响较少,有利于母婴健康。Objective To investigate the effects of dexmedetomidine combined with sevoflurane on cesarean section anesthesia in patients with preeclampsia.Methods The clinical data of each 62 patients with preeclampsia who underwent cesarean section anesthesia with sevoflurane anesthesia(control group)and dexmedetomidine combined with sevoflurane anesthesia(observation group)were retrospectively analyzed.The vital signs before administration(t0),after anesthesia induction(t1),at fetal delivery(t2)and at extubation(t3)[mean arterial pressure(MAP),heart rate(HR)and oxygen saturation(SpO2)]and stress response before operation and immediately after operation[cortisol(Cor)and norepinephrine(NE)]were compared between the 2 groups.The anesthetic sedative effects(Richmond sedation score),perioperative adverse reactions(chills,digestive tract reaction,hypotension and bradycardia)and neonatal Apgar score at 1 and 5 min after birth were recorded at t1,t2 and t3.Results The changes of MAP and HR in the 2 groups showed t0>t3>t2>t1(P<0.05).At t0and t1,there was no significant difference in MAP and HR between the 2 groups(P>0.05).At t2 and t3,the MAP and HR in observation group were lower than those in control group,the difference is statistically significant(P<0.05).There was no significant difference in the SpO2 between the 2 groups at each time point and within-groups(P>0.05).The plasma Cor and NE levels immediately after operation were higher in the 2 groups than those before operation,the difference is statistically significant(P<0.05),and the levels in control group were higher than those in observation group,the difference is statistically significant(P<0.05).At t1,there was no significant difference in the Richmond score between the 2 groups(P>0.05).At t2 and t3,the Richmond score in observation group was lower than that in control group,the difference is statistically significant(P<0.05).There were no significant differences in the perioperative adverse reactions and the neonatal Apgar scores at 1 and 5 min after birth between the

关 键 词:右美托咪定 七氟醚 复合麻醉 子痫前期 剖宫产 

分 类 号:R971[医药卫生—药品]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象