血清微小RNA-433和转化生长因子-β1在扩张型心肌病合并慢性心力衰竭患者中的变化及临床意义  

Changes and clinical value of serum microRNA-433 and transforming growth factor-β1 in dilated cardiomyopathy patients with chronic heart failure

作　　者：杜春书 王军[2] 黄佩花 吴多省 陈梦飞 Du Chunshu;Wang Jun;Huang Peihua;Wu Duosheng;Chen Mengfei(Department of Cardiology,Dongfang Hospital of Dongfang City,Dongfang 572600,China;不详)

机构地区：[1]海南省东方市东方医院心血管内科,572600 [2]海南医学院第一附属医院心血管内科

出　　处：《临床内科杂志》2020年第5期342-345,共4页Journal of Clinical Internal Medicine

摘　　要：目的探讨血清微小RNA(miR)-433和转化生长因子(TGF)-β1在扩张型心肌病(DCM)合并慢性心力衰竭(CHF)患者中的变化及临床意义。方法纳入DCM合并CHF患者106例(DCM合并CHF组),另选取100例健康体检者作为对照组,检测并比较两组受试者血清miR-433和TGF-β1水平,分析其与纽约心脏病学会(NYHA)心功能分级、N末端脑利钠前体(NT-proBNP)、左心室舒张末期内径(LVEDd)、左心室射血分数(LVEF)的相关性。采用多因素logistic回归分析评估血清miR-433和TGF-β1对DCM合并CHF患者心功能损伤的影响。结果DCM合并CHF组患者血清miR-433和TGF-β1水平均高于对照组(P<0.05)。Spearman等级相关分析结果显示,DCM合并CHF患者血清miR-433和TGF-β1水平均与NYHA心功能分级呈正相关(P<0.001)。Pearson相关分析结果显示,DCM合并CHF患者血清miR-433和TGF-β1水平均与NT-proBNP、LVEDd呈正相关,与LVEF呈负相关(P<0.001)。多因素logistic回归分析结果显示,血清miR-433和TGF-β1均是DCM合并CHF患者心功能损伤加重的独立危险因素(P<0.05)。结论DCM合并CHF患者血清miR-433和TGF-β1水平均升高,且均与NYHA心功能分级呈正相关,对于危险分层有一定的临床指导意义。Objective To explore the changes and clinical value of microRNA(miR)-433 and transforming growth factor(TGF)-β1 in dilated cardiomyopathy(DCM)patients with chronic heart failure(CHF).Methods A total of 106 DCM patients with CHF(DCM with CHF group)were concluded and 100 healthy examiners were selected as control group.Serum miR-433 and TGF-β1 levels were detected and compared.Relationship among serum miR-433,TGF-β1 levels and New York Heart Disease Assocation(NYHA)cardiac function classification,N terminal pro-B type natriuretic peptide(NT-proBNP),left ventricular end-diastolic dimension(LVEDd)and left ventricular ejection fraction(LVEF)were analyzed.Multivariate logistic regression analysis was conducted to evaluate effect of serum miR-433 and TGF-β1 on cardiac function injury in DCM patients with CHF.Results Serum miR-433 and TGF-β1 levels in patients of DCM and CHF group were higher than those in control group(P<0.05).Results of Spearman rank correlation analysis showed that serum miR-433 and TGF-β1 levels in DCM patients with CHF were both positively correlated with NYHA cardiac function classification(P<0.001).Results of Pearson correlation analysis showed that serum miR-433 and TGF-β1 levels were both positively correlated with NT-proBNP,LVEDd,while they were both negatively correlated with LVEF(P<0.001).Results of multivariate logistic regression analysis showed that serum miR-433 and TGF-β1 were independent risk factors for the aggravation of cardiac function in DCM patients with CHF(P<0.05).Conclusion Serum miR-433 and TGF-β1 levels increase in DCM patients with CHF,and they are both positively correlated with NYHA cardiac function classification,which has certain clinical instructional significance for risk stratification.

关 键 词：微小RNA-433 转化生长因子-Β1 扩张型心肌病 慢性心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病] R542.2[医药卫生—内科学]