原发性高血压病患者血浆同型半胱氨酸水平与心血管事件的相关性  

Correlation of plasma homocysteine level with cardiovascular events in patients with hypertension

作　　者：符少萍[1] 刁冬梅[1] 陈焕清[1] 杨雪梅[1] Fu Shaoping

机构地区：[1]中山大学孙逸仙纪念医院,广东广州510120

出　　处：《中医临床研究》2020年第16期67-69,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨原发性高血压病患者血同型半胱氨酸水平与心血管事件的相关性。方法:选取我院住院的原发性高血压病患者500例,按血浆同型半胱氨酸(Homocysteine,Hcy)水平分为观察组(Hcy≥10μmol/L)242例和对照组(Hcy<10μmol/L)258例,检测两组的腰围、体质量指数(Body Mass Index,BMI)、收缩压(Systolic Blood Pressure,SBP)、舒张压(Diastolic Blood Pressure,DBP)、空腹血糖(Glucose,GLU)、总胆固醇(Total Cholesterol,TC)、甘油三脂(Triglyceride,TG)、低密度脂蛋白(Low Density Lipoprotein Cholestero,LDL-C)、Hcy,并随访1年,记录两组心血管事件的发生情况,分析发生心血管事件的危险因素。结果:两组间的腰围、BMI、SBP、DBP、GLU、Tc、TG、LDL-C相比较差异均无统计学意义(P>0.05),Hcy比较差异有统计学意义(P<0.05)。两组心血管事件的发生率差异比较有统计学意义(P<0.001)。血浆Hcy水平是原发性高血压病患者发生心血管事件的危险因素[OR=2.217,95%CI(1.205-3.745),P=0.007]。结论:血浆Hcy水平是原发性高血压病患者发生心血管事件的危险因素。Objective:To investigate the correlation of Hcy level with cardiovascular events in patients with hypertension.Methods:500 patients were divided into the observation group(242 cases,Hcy≥10μmol/L)and the control group(258 cases,Hcy﹤10μmol/L).BMI,SBP,DBP were measured.GLU,TC,TG,LDL-C and Hcy were determined for all patients.The occurrence of cardiovascular events was recorded during 1 year follow-up.The risk factors of cardiovascular events were alalysed.Results:There was no significant difference in the weist,BMI,SBP,DBP,GLU,TC,TG,LDL-C(P>0.05)and significant difference in Hcy between two groups.The occurrence rate of cardiovascular events had significant difference between two groups(P﹤0.001).The serum Hcy level was one of the risk factors of cardiovascular events[OR=2.217,95%CI(1.205-3.745),P=0.007].Conclusion:The plasma Hcy level was one of the risk factors of cardiovascular events in patients with hypertension.

关 键 词：原发性高血压病 同型半胱氨酸 心血管事件 

分 类 号：R544.1[医药卫生—心血管疾病]