水胶体敷料联合重组牛碱性成纤维细胞生长因子外用凝胶治疗新生儿尿布性皮炎的临床观察  

Clinical observation of hydrocolloid dressing combined with topical gel of recombinant bovine basic fibroblast growth factor in treatment of neonatal diaper dermatitis

作　　者：王宁[1] 王小虎[2] WANG Ning;WANG Xiaohu(Department of Burn and Wound Repair Surgery,East Branch,Zibo Central Hospital in Shandong Province,Zibo 276000,China;Department of Neonatology,the Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]山东省淄博市中心医院东院烧伤与创面修复外科,山东淄博276000 [2]青岛大学附属医院新生儿科,山东青岛266000

出　　处：《中国现代医生》2020年第15期76-79,共4页China Modern Doctor

摘　　要：目的观察水胶体敷料联合重组牛碱性成纤维细胞生长因子外用凝胶在新生儿尿布性皮炎中的治疗效果。方法采用水胶体敷料联合重组牛碱性成纤维细胞生长因子外用凝胶治疗新生儿尿布性皮炎96例,患儿均来自淄博市中心医院2018年9月~2019年9月收治病例,患儿依随机数字表法分为观察组、对照组各48例,观察组创面采用水胶体敷料联合重组牛碱性成纤维细胞生长因子外用凝胶应用,对照组予以常规外科换药,比较两组的临床疗效,包括有效率、尿布性皮炎消退时间及不良事件发生率。结果观察组治疗的总有效率(91.67%)明显高于对照组(64.58%),差异有统计学意义(P<0.05)。观察组的轻度、中度、重度患儿治愈率(分别为93.10%,91.67%,85.71%)明显高于对照组轻度、中度、重度组(分别为75.00%,57.14%,33.33%),差异有统计学意义(P值分别为0.041,0.033,0.023)。观察组的治疗时间为(93.26±21.83)h,明显短于对照组(112.39±48.25)h,差异有统计学意义(P<0.05)。观察组的不良反应发生率(6.25%)明显低于对照组(22.92%),差异有统计学意义(P<0.05),提示水胶体敷料联合重组牛碱性成纤维细胞生长因子外用凝胶治疗尿布性皮炎较常规疗法疗效为佳。结论水胶体敷料联合重组牛碱性成纤维细胞生长因子外用凝胶对新生儿尿布性皮炎疗效显著,同常规换药相比,可有效消除皮损症状,加快皮肤愈合,减少不良事件发生,值得临床中推广应用。Objective To observe the therapeutic effect of hydrocolloid dressing combined with topical gel of recombinant bovine basic fibroblast growth factor in neonatal diaper dermatitis.Methods 96 cases of neonatal diaper dermatitis who were treated with hydrocolloid dressing combined with topical gel of recombinant bovine basic fibroblast growth factor were selected.The children patients were all admitted to Zibo Central Hospital from September 2018 to September 2019.The children patients were divided into the observation group and control group by random number table method,with 48 cases in each group.The wounds in the observation group were applied with hydrocolloid dressing combined with topical gel of recombinant bovine basic fibroblast growth factor,and the control group was given routine surgical dressing change.The clinical efficacy was compared between the two groups,including the effectiveness,the resolution time of diaper dermatitis and the incidence rate of adverse events.Results The total effective rate of treatment in the observation group(91.67%)was significantly higher than that in the control group(64.58%),and the difference was statistically significant(P<0.05).The cure rates of mild,moderate,and severe children patients in the observation group(93.10%,91.67%,85.71%,respectively)were significantly higher than those in the control group(75.00%,57.14%,33.33%),and the differences between both groups were statistically significant(P values were 0.041,0.033,0.023).The treatment time in the observation group was(93.26±21.83)hours,which was significantly shorter than that of(112.39±48.25)hours in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group(6.25%)was significantly less than that in the control group(22.92%),and the difference was statistically significant(P<0.05).It was suggested that hydrocolloid dressing combined with topical gel of recombinant bovine basic fibroblast growth factor was better than conventional therapy

关 键 词：水胶体敷料 重组牛碱性成纤维细胞生长因子外用凝胶 新生儿 尿布性皮炎 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]