绿原酸抑制TLR4/NF-κB通路诱导巨噬细胞源性泡沫细胞凋亡的进展分析  

Analysis on the progression of macrophage-derived foam cell apoptosis induced by chlorogenic acid inhibition of TLR4/NF-κB pathway

作　　者：罗南 叶蔚[2] 俞蕾敏 LUO Nan;YE Wei;YU Leimin(Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China;Department of Gastroenterology,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou 310007,China)

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]杭州市中医院消化科,浙江杭州310007

出　　处：《中国现代医生》2020年第15期189-192,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2019RC250)。

摘　　要：绿原酸是中药金银花当中的主要成分,对于炎症反应的抑制可以起到一定的作用和效果。绿原酸对于巨噬细胞模型上具备抗炎活性的作用,本文先就绿原酸在巨噬细胞源性泡沫凋亡当中的诱导作用进行分析,总结当前学者在这方面的研究进展,为之后的后期研究奠定理论基础。Chlorogenic acid is the main component of honeysuckle as a traditional Chinese medicine,which can play a certain role in the inhibition of inflammatory reaction.Chlorogenic acid has anti-inflammatory activity in macrophage model.In this paper,the induction of chlorogenic acid in macrophage-derived foam cell apoptosis was firstly analyzed,and the current research progress achieved by various scholars in this field was then summarized so as to lay a theoretical foundation for the later research.

关 键 词：绿原酸 TLR4/NF-κB通路 诱导作用 巨噬细胞 源性泡沫细胞 

分 类 号：R285[医药卫生—中药学]