寻常型白癜风与晕痣患者外周血T淋巴细胞亚群及Th1/Th2、Th17/Treg细胞平衡比较  

Comparison of peripheral blood T lymphocyte subsets and balances of Th1/Th2 and Th17/Treg between patients with vitiligo vulgaris and those with Halo nevus

作　　者：曹伟[1] 冯玉婷[1] 王小媛[1] 王颖娟[1] 康乐[1] 易海玲 杨曦 李青青 李习梅 李宝[1] 李超[1] CAO Wei;FENG Yuting;WANG Xiaoyuan;WANG Yingjuan;KANG Le;YI Hailing;YANG Xi;LI Qingqing;LI Ximei;LI Bao;LI Chao(Department of Dermatology,Baoji City Central Hospital,Baoji,Shaanxi,721008)

机构地区：[1]陕西省宝鸡市中心医院皮肤科,陕西宝鸡721008

出　　处：《实用临床医药杂志》2020年第12期84-86,共3页Journal of Clinical Medicine in Practice

基　　金：陕西省科技厅重点研发计划项目(2017SF-153)。

摘　　要：目的比较寻常型白癜风与晕痣患者外周血辅助性T细胞1(Th1)、Th2、Th17、调节性T淋巴细胞(Treg细胞)水平,以及Th1与Th2比值(Th1/Th2)、Th17与Treg比值(Th17/Treg)。方法选取43例进展期寻常型白癜风患者和37例Ⅰ、Ⅱ阶段晕痣患者进行研究,均采集外周血进行流式细胞学检测。对照组(n=15)为本院常规体检健康人群。结果寻常型白癜风组病灶多部位者比率显著高于晕痣组多部位者比率(P<0.05)。寻常型白癜风组、晕痣组及对照组Th2、Th17细胞水平及Th17/Treg有显著差异(P<0.05),Th1、Treg细胞及Th1/Th2无显著差异(P>0.05)。结论寻常型白癜风与晕痣患者外周血Th1、Th2、Th17及Treg细胞变化存在差异,表现为寻常型白癜风患者外周血Th17细胞增高更为显著,而晕痣患者外周血Th2细胞下降更显著。Objective To compare the levels of peripheral blood helper T cell 1(Th1),Th2,Th17,regulatory T lymphocyte(Treg cells)and ratios of Th1 to Th2(Th1/Th2),Th17 to Treg(Th17/Treg)between patients with vitiligo vulgaris and those with Halo nevus.Methods Totally 43 patients with advanced vitiligo vulgaris and 37 patients with stageⅠandⅡof Halo nevus were collected and conducted with flow cytometry after collecting peripheral blood samples.Fifteen healthy people with routine physical examination were selected as control group.Results The ratio of patients with multiple sites of lesions in vitiligo vulgaris group was significantly higher than that in Halo nevus group(P<0.05).There were significant differences in levels of Th2 and Th17 cells and Th17/Treg between vitiligo vulgaris group,Halo nevus group and control group(P<0.05),but there were no significant differences in Th1,Treg cells and Th1/Th2 among three groups(P>0.05).Conclusion There are differences in changes of peripheral blood Th1,Th2,Th17 and Treg cells between patients with vitiligo vulgaris and those with Halo nevus,which represent as the obvious increase of peripheral blood Th17 cells in patients with vitiligo vulgaris and the obvious decrease of peripheral blood Th2 cells in those with Halo nevus.

关 键 词：寻常型白癜风 晕痣 辅助性T细胞 调节性T淋巴细胞 细胞平衡 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]