中医药治疗慢性心力衰竭的药理机制与研究进展  

Pharmacological mechanism and research progress of traditional Chinese medicine in the treatment of chronic heart failure

作　　者：王居平 杨维伦 施乐[1] WANG Juping;YANG Weilun;SHI Le(Beichen District Hospital of Traditional Chinese Medicine in Tianjin,Tianjin,300400)

机构地区：[1]天津市北辰区中医医院,天津300400

出　　处：《实用临床医药杂志》2020年第12期125-128,共4页Journal of Clinical Medicine in Practice

摘　　要：慢性心力衰竭是危害人类健康的严重疾病,具有较高的发病率与死亡率。慢性心力衰竭病机复杂,中医治疗具有独特的优势。现阶段研究已对慢性心力衰竭有着较为深入的认知,其中神经体液、炎症反应、心室重构、氧化应激、血管内皮功能与心肌能量代谢等均与本病的发生及进展过程密切相关。本研究通过分析慢性心力衰竭的病因病机,并从多机制、多环节、多靶点、多方位的角度对中医药治疗的药理机制与研究进展进行综述,为完善临床治疗方案提供可靠的参考依据。Chronic heart failure,a severe disease threatening human health,has complex pathogenesis and higher incidence rate as well as mortality rate.Traditional Chinese medicine presents unique advantages in treating the disease.At present,the researches have obtained more in-depth understanding of chronic heart failure,and their findings showed that neurohumoral control,inflammatory response,ventricular remodeling,oxidative stress,vascular endothelial function and myocardial energy metabolism are closely related to the occurrence and progress of the disease.Through the analysis of the etiology and pathogenesis of chronic heart failure,and in the perspective of multi-mechanism,multi-link,multi-target,multi-dimension,pharmacological mechanism as well as research progress of traditional Chinese medical treatment were reviewed so as to provide a reliable reference for improving the clinical treatment program.

关 键 词：中医药 慢性心力衰竭 药理机制 心室重构 氧化应激反应 炎症反应 心肌能量代谢 

分 类 号：R541.6[医药卫生—心血管疾病]