A circular microreaction method to the safe and efficient synthesis of 3-methylpyridine-N-oxide  

作　　者：Funing Sang Jinpei Huang Jianhong Xu 

机构地区：[1]The State Key Lab of Chemical Engineering,Department of Chemical Engineering,Tsinghua University,Beijing 100084,China

出　　处：《Chinese Journal of Chemical Engineering》2020年第5期1320-1325,共6页中国化学工程学报（英文版）

基　　金：the supports of the National Natural Science Foundation of China(21991101,2191100);the Key Project of Science&Technology Department of Sichuan Province(2017JZ0011)for this work。

摘　　要：3-Methylpyridine-N-oxide is an essential intermediate in the preparation of 2-chloro-5-methylpyridine,which can be used to synthesize nicotine insecticides such as imidacloprid and acetamiprid.The traditional method of production of 3-methylpyridine-N-oxide is catalytic oxidation of 3-methylpyridine in semi-batch reactors.Due to strong exothermic reaction and explosive property of 3-methylpyridine,the reaction efficiency and safety is low using batch technology.Therefore,the development of a safer and efficient 3-methylpyridine-N-oxide production process is very necessary in industrial production.In this paper,microreaction systems were introduced into the preparation of 3-methylpyridine-N-oxide.The comparison of three different methods(traditional semibatch method,co-current microreaction method,and circular microreaction method)showed that the circular microreaction method was the most applicable,with relative higher product yield(~90%),less side reaction and better reaction control.

关 键 词：Flow synthesis Hydrogen peroxide OXIDATION Microreaction system 

分 类 号：O626.32[理学—有机化学]