超声靶向微泡破坏技术介导基因转染的研究进展  

Research progress in gene transfection mediated by ultrasound-targeted microbubble destruction technology

作　　者：张月[1] 周厚妊 辛莹 李诗慧 刘小奇 刘治军[1] ZHANG Yue;ZHOU Houren;XIN Ying;LI Shihui;LIU Xiaoqi;LIU Zhijun(Department of Ultrasound,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院超声科,沈阳市110004

出　　处：《临床超声医学杂志》2020年第7期523-525,共3页Journal of Clinical Ultrasound in Medicine

基　　金：国家自然科学基金项目(81801712)。

摘　　要：基因转染技术的高速发展不仅革新了生物学和医学许多基本问题的研究,也推动了诊断和治疗的进步。基因作为核酸类生物活性大分子,极易在体内降解,因此传递基因的载体尤为重要。超声靶向微泡破坏(UTMD)技术利用超声波和微泡之间的相互作用,以及其产生的生物学效应,使微泡携基因进行转染,并与多种载体联合应用,为疾病的治疗提供了有效手段。本文就UTMD技术介导基因转染的研究进展进行综述。The rapid development of gene transfection technology has not only revolutionized the research of many basic problems in biology and medicine,but also promoted the progress of diagnosis and treatment.As a biologically active macromolecule of nucleic acids,the gene is easily degraded in the body,so the carrier for gene delivery is particularly important.Ultrasound-targeted microbubble destruction technology(UTMD)utilizes the interaction between ultrasound and microbubbles and the biological effects it produces to enable microbubbles to carry genes for gene transfection and can be used in combination with a variety of vectors.The treatment of a variety of diseases provides an effective means.This article reviews the recent advances in gene transfection by ultrasound-targeted microbubble destruction.

关 键 词：超声靶向微泡破坏技术 基因转染 微泡 载体 

分 类 号：R445.1[医药卫生—影像医学与核医学]