补脾益肾法对慢性肾衰竭维持性透析合并肾性贫血患者疗效及血生化指标影响  

Efficacy of Tonifying Spleen and Nourishing Kidney on Chronic Renal Failure Patients Undergoing Maintenance Dialysis Combined with Renal Anemia and Its Influence on Blood Biochemical Indexes

作　　者：赵涛[1] 朱丹[1] 史焱[1] 侯小雪[1] 温旭 王鹏飞[1] 栗睿[1] ZHAO Tao;ZHU Dan;SHI Yan;HOU Xiaoxue;WEN Xu;WANG Pengfei;LI Rui(The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,Liaoning,China)

机构地区：[1]辽宁中医药大学附属第二医院,辽宁沈阳110034

出　　处：《辽宁中医药大学学报》2020年第5期67-70,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81702622);辽宁省中医药临床学(专)科能力建设项目(2013-Lnzyxzk-04);辽宁省教育厅科学研究一般项目(L2012346);辽宁省科学事业公益研究基金(2012002012);沈阳市科技计划(F15-139-9-41)。

摘　　要：目的探讨补脾益肾法对慢性肾衰竭维持性透析合并肾性贫血患者疗效及血生化指标的影响。方法选取2017年1月—2019年1月收治的慢性肾衰竭维持性透析合并肾性贫血患者64例,依据随机数字表法随机分为对照组和治疗组,各32例,对照组采用常规西药进行治疗,治疗组在其基础上加用补脾益肾法,疗程均为12周。对比两组中医症状积分变化情况,患者治疗前后血常规及血生化指标改善情况,比较两组临床总有效率。结果两组治疗后中医症状积分均较治疗前降低(P<0.05),治疗组降低幅度较对照组更明显(P<0.05),说明治疗组中医症状好转更显著;治疗后,红细胞压积(Hct)、红细胞计数(RBC)、血红蛋白(Hb)等血常规指标均改善(P<0.05),且治疗组改善更显著(P<0.05);比较治疗前后血清胱抑素C(Cys C)、肌酐(Scr)、C反应蛋白(CRP)、尿素氮(Bun)等血生化指标变化情况,两组各指标均呈下降趋势(P<0.05),且相较于对照组,治疗组下降幅度更显著(P<0.05),说明治疗组可有效改善患者肾功能;对照组临床总有效率为71.87%,治疗组临床总有效率为93.75%,治疗组较对照组临床疗效更佳(P<0.05)。结论补脾益肾法具有补脾养血、补肾益气之效,可以改善慢性肾衰竭维持性透析合并肾性贫血患者临床症状和体征,能够改善贫血,改善肾功能,对于慢性肾衰竭维持性透析合并肾性贫血有较好的的治疗效果,值得临床推广应用。Objective The purpose of this study was to investigate the effect of tonifying spleen and nourishing kidney on chronic renal failure patients undergoing maintenance dialysis combined with renal anemia and its influence on blood biochemical indexes.Methods 64 chronic renal failure patients undergoing maintenance dialysis combined with renal anemia admitted to our hospital from January 2017—January 2019 were selected and randomly divided into treatment group and control group with 32 cases in each group according to the table of random number.The control group was administered with conventional Western medicine treatment,while the treatment group was administered with tonifying spleen and nourishing kidney method on the basis of the control group.The patients in both groups were treated for 12 weeks.Compared the changes of TCM symptom scores,the improvement of blood routine and blood biochemical indexes before and after treatment in both groups,and compared the clinical total effective rate between the two groups.Results After treatment,the scores of TCM symptoms in both groups were lower than before treatment(P<0.05),and the reduction of scores in the treatment group was more significant than that in the control group(P<0.05),which shows that the symptoms of TCM in the treatment group improved more significantly than those in the control group.After treatment,the blood routine index such as hematocrit(Hct),red blood cell count(RBC),haemoglobin(Hb),etc.,all improved(P<0.05),and the improvement in treatment group was more significant(P<0.05).Compared the changes of blood biochemical indexes such as serum cystatin C(Cys C),creatinine(Scr),C reactive protein(CRP),urea nitrogen(BUN),etc.before and after treatment,the results showed that each index in both groups showed a downward trend(P<0.05),and the decrease in the treatment group was more significant when compared with the control group(P<0.05),indicating that the treatment group can effectively improve the renal function of patients.The total clinical effective r

关 键 词：补脾益肾法 慢性肾衰竭 维持性透析 肾性贫血 肾功能 

分 类 号：R692.5[医药卫生—泌尿科学]