囊膜糖蛋白gE对α疱疹病毒毒力的影响  

Effect of Alphaherpesvirus Glycoprotein gE on Virulence

作　　者：黄雅琳 程安春[1,2,3] 汪铭书[1,2,3] HUANG Yalin;CHENG Anchun;WANG Mingshu(Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China;Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China;Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China)

机构地区：[1]四川农业大学动物医学院禽病防治研究中心,成都611130 [2]四川农业大学预防兽医研究所,成都611130 [3]四川农业大学动物疫病与人类健康四川省重点实验室,成都611130

出　　处：《畜牧兽医学报》2020年第7期1506-1514,共9页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：“十三五”国家重点研发计划(2017YFD0500800);国家现代农业(水禽)产业技术体系专项(CARS-42-17);国家农业产业技术体系四川兽药创新团队专项(SCCXTD-2020-18);四川省重点研发计划项目(2018NZ0005)。

摘　　要：近年来,α疱疹病毒的囊膜糖蛋白gE在病毒细胞间传递、神经系统入侵、免疫逃避等方面的研究取得新的进展。gE能促进合胞体形成,影响病毒的顺行、逆行神经传导,也是第一个报道可以抑制浆细胞样树突状细胞产生Ⅰ型干扰素的病毒蛋白。本文对α疱疹病毒囊膜糖蛋白gE与毒力之间的关系进行阐述,以期为α疱疹病毒gE的功能研究提供参考。In recent years,new progress has been made in the research of glycoprotein gE of alphaherpesvirus in virus intercellular transmission,nervous system infection,and immune evasion.gE is involved in syncytium formation,anterograde and retrograde neurotransmission,and is also the first reported viral protein that inhibits the activation of plasmacytoid dendritic cells to produce type I interferon.This summary reviews the relationship between gE and virulence to provide useful information for the further study of gE.

关 键 词：α疱疹病毒 囊膜糖蛋白gE 毒力 免疫逃避 神经毒力 

分 类 号：S852.659.1[农业科学—基础兽医学]