血管紧张素转换酶2抗新冠病毒药理作用机制的研究进展  

Research progress in the pharmacological mechanism of angiotensin-converting enzyme 2 against SARS-CoV-2

作　　者：齐阳 黄爱文 宋洪涛 QI Yang;HUANG Ai-wen;SONG Hong-tao(Department of Pharmacy,No.900 Hospital of the Chinese PLA Joint Support Forces,Fujian Fuzhou 350025,China)

机构地区：[1]中国人民解放军联勤保障部队第九〇〇医院药学科,福建福州350025

出　　处：《中国医院药学杂志》2020年第9期968-971,共4页Chinese Journal of Hospital Pharmacy

摘　　要：血管紧张素转换酶2(ACE2)是肾素-血管紧张素系统负向调节血压的关键因子,主要分布在心脏、肾脏和胃肠等部位。最新研究发现ACE2是新型冠状病毒(SARS-CoV-2)入侵的功能性受体。新型冠状病毒和SARS相关冠状病毒(SARS-CoV)都能利用宿主细胞表面ACE2作为受体,与病毒刺突糖蛋白(Spike)受体结合结构域(RBD)结合发生相互作用,介导病毒入侵宿主细胞。回顾性分析ACE2在抗SARS-CoV中的研究进展,结合目前对新型冠状病毒肺炎(COVID-19)疫情防治的认识及Spike-ACE2蛋白相互作用的最新研究成果,对ACE2抗新型冠状病毒的药理作用机制研究进行简要综述,以期为新冠肺炎抗病毒特效药的研发提供参考。Angiotensin-converting enzyme 2(ACE2)is a key factor in the negative regulation of blood pressure by the renin-angiotensin system,which is mainly distributed in the heart,kidney and gastrointestinal tract.Recent studies have found that ACE2 is a functional receptor for invasion by novel coronaviruses(SARS-CoV-2).Both novel coronaviruses and SARS-associated coronaviruses(SARS-CoV)can utilize host cell surface ACE2 as a receptor and interact with the receptor binding domain of the viral spike glycoprotein(Spike)to mediate viral invasion of host cells.This paper retrospectively analyzed the research progress of ACE2 in anti-SARS-CoV,combined with the current understanding of the epidemic prevention and treatment of novel coronavirus pneumonia(COVID-19)and the latest research results of Spike-ACE2 protein interaction,the pharmacological mechanism of ACE2 against novel coronavirus was briefly reviewed in order to provide a reference for the research and development of antiviral specific drugs for new coronary pneumonia.

关 键 词：血管紧张素转换酶2 刺突糖蛋白 新型冠状病毒 新型冠状病毒肺炎 SARS相关冠状病毒 

分 类 号：R969[医药卫生—药理学]