3,5-二溴-2-氨基吡嗪的绿色合成工艺  

Green Synthesis of 3,5-Dibromopyrazin-2-amine

作　　者：刘正文 胡宇超 周立超 何强强 LIU Zheng-wen;HU Yu-chao;ZHOU Li-chao;HE Qiang-qiang(Zhejiang Zhebang Pharmaceutical Co.,Ltd.,Shaoxing,Zhejiang 312300,China)

机构地区：[1]浙江浙邦制药有限公司,浙江绍兴312300

出　　处：《浙江化工》2020年第7期19-21,共3页Zhejiang Chemical Industry

摘　　要：以价廉易得的2-氰基吡嗪为起始原料,经过水解、霍夫曼重排、脱羧、溴代连续反应得到3,5-二溴-2-氨基吡嗪。产物结构经H NMR和MS确认,与标准图谱相符。本工艺反应时间短,反应条件温和,具有较高的应用价值。Using inexpensive and easily available 2-cyanopyrazine as the starting material,3,5-dibromopyrazin-2-amine was obtained through hydrolysis,Huffman rearrangement,decarboxylation and continuous bromination.The structure of the product was confirmed by H NMR and MS,which was consistent with the standard spectrum.The process has short reaction time and mild reaction conditions,and has high application value.

关 键 词：2-氰基吡嗪 霍夫曼重排 NBS 3 5-二溴-2-氨基吡嗪 

分 类 号：TQ463[化学工程—制药化工]