O2参与下FeCl2催化的分子内氧化反应构建异噁唑杂环  

FeCl2-Catalyzed Intramolecular Aerobic Reaction for Construction of Isoxazoles Heterocycle

作　　者：阿布力米提·阿布都卡德尔[1] 汪荣 买尔哈巴·买买提 刘晨江[1] Abdukader Ablimit;Wang Rong;Mamat Marhaba;Liu Chenjiang(College of Chemical and Chemical Engineering,Xinjiang University,Urumqi 830046)

机构地区：[1]新疆大学化学化工学院,乌鲁木齐830046

出　　处：《有机化学》2020年第6期1697-1703,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21562039)资助项目。

摘　　要：发展了一种廉价金属盐FeCl2催化氧气氧化下,高效、环保且简洁合成多取异噁唑衍生物的新方法.通过对金属盐来源和碱等反应条件的优化,确立了最佳的反应条件.在此反应条件下合成了19个新型多取代3,5-二芳基异噁唑衍生物,并成功培养了一个单晶,产率在80%-90%之间.经过^1H NMR、^13C NMR、元素分析及X单晶衍射确证了所得目标化合物的结构.A simple,practical and highly efficient synthesis of multi substituted isoxazole derivatives via cheap metal salt FeCl2-catalyzed direct aerobic oxidative has been developed.Nineteen novel multi-substituted 3,5-diaryl isoxazole derivtaves were synthesized and a single crystal was successfully cultivated.The products were get with about 70%~90%yields under mild conditions.The structures of products were fully characterized by ^1 H NMR,^13C NMR,elemental analysis and X-ray crystal.

关 键 词：FeCl2催化 氧气氧化 异噁唑 杂环 N—O键形成 

分 类 号：TQ463[化学工程—制药化工]