二(4-苄氧苯基)二硒醚的设计与制备:一种铜残留清除剂  

Design and Synthesis of 1,2-Bis(4-(benzyloxy)phenyl)diselane:A Scavenger for Residual Copper

作　　者：葛颜玉 孔晶 杨成根 杨倩 张旭 Ge Yanyu;Kong Jing;Yang Chenggen;Yang Qian;Zhang Xu(School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou,Jiangsu 225002;Jiangsu College of Tourism,Yangzhou,Jiangsu 225000)

机构地区：[1]扬州大学化学化工学院,江苏扬州225002 [2]江苏旅游职业学院,江苏扬州225000

出　　处：《有机化学》2020年第6期1760-1765,共6页Chinese Journal of Organic Chemistry

基　　金：江苏省优势学科以及江苏省高校品牌专业建设资助项目.

摘　　要：通过往分子中引入苄氧取代基所制备出的二(4-苄氧苯基)二硒醚,与普通富电子或缺电子二硒醚相比,更能够清除铜污染物.在室温下,该化合物4h内即可完全清除二价铜离子.该物质可被应用到伊马替尼全合成中,以降低产品中的催化剂铜残留.通过加入1 mol%的二(4-苄氧苯基)二硒醚,可将伊马替尼碱产品中的铜残留抑制到10^-7.上述结果表明该有机硒化合物在制药工业有着很好的应用潜力.报道了一种新颖的利用硒与铜配位作用清除铜残留的方法.由于硒元素安全、可降解,该方法有望被应用于制药工业.By introducing benzyloxy into the molecule,the as-prepared 1,2-bis(4-(benzyloxy)phenyl)diselane showed superior activity in copper pollutant elimination over simple diselenides in regardless of their electron-donating or electron-withdrawing substituents.The copper-adsorption process occurred smoothly at room temperature and could completely remove the Cu2+ions within 4 h.The compound has been successfully employed in our Imatinib base synthetic project to reduce the catalytic Cu residue in product.By using only 1 mol%1,2-bis(4-(benzyloxy)phenyl)diselane,the Cu residue in the produced Imatinib base could be depressed to be less than 10^-7,showing good application potential of torganoselenium compound in pharmaceutical industry.A novel method for removing copper residue is reported and it may be applied in pharmaceutical industry owing to the safe and metabolizable features of selenium.

关 键 词：硒 有机硒化学 二硒醚 铜 重金属清除 

分 类 号：O623.423[理学—有机化学]