无金属条件下通过与醚的自由基偶联反应实现N-氧化物的C-2烷基化反应  

Metal-Free C-2 Alkylation of N-Oxides with Ethers via Radical Cross-Coupling Reactions

作　　者：董道青[1] 李光辉 陈德茂 孙媛媛 韩晴晴 王祖利 徐鑫明 于贤勇[3] Dong Daoqing;Li Guanghui;Chen Demao;Sun Yuanyuana;Han Qingqing;Wang Zuli;Xu Xinming;Yu Xianyong(College of Chemistry and Pharmaceutical Sciences,Qingdao Agricultural University,Qingdao,Shandong 266109;College of Chemistry and Chemical Engineering,Yantai University,Yantai,Shandong 264005;School of Chemistry and Chemical Engineering,Hunan University of Science and Technology,Xiangtan,Hunan 411201)

机构地区：[1]青岛农业大学化学与药学院,山东青岛266109 [2]烟台大学化学化工学院,山东烟台264005 [3]湖南科技大学化学化工学院,湖南湘潭411201

出　　处：《有机化学》2020年第6期1766-1771,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21772107);山东省重点研发计划(No.2019GSF108017)资助项目。

摘　　要：在无金属条件下通过自由基偶联反应,实现了醚类与N-氧化物的C-2烷基化反应,反应条件温和,只需加入氧化剂二叔丁基过氧化物(DTBP)就能够以中等至高产率获得各种所需产物.The C-2 alkylation of ethers and N-oxides was achieved via free radical coupling reaction under metal-free conditions.The reaction conditions are mild,and the desired products can be obtained in medium to high yields with the addition of the oxidant di-tert-butyl peroxide(DTBP).

关 键 词：喹啉-N-氧化物 醚 烷基化 自由基偶联 

分 类 号：O626.323[理学—有机化学]