β-arrestin在神经精神疾病中的作用及偏向型配基的应用前景  

β-arrestin and its biased ligands in neuropsychological diseases

作　　者：鲁明[1] LU Ming(Department of Pharmacology,Jiangsu Key Laboratory of Neurodegenerative Diseases,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学药理学系,江苏省神经退行性疾病重点实验室,江苏南京211166

出　　处：《南京医科大学学报（自然科学版）》2020年第5期623-626,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：β-arrestin参与调节大量生理和病理进程,例如心血管和胃肠道系统疾病、肾脏和肺功能异常、炎症和代谢紊乱、骨矿物质稳态维持、生殖和中枢神经系统疾病等。随着对β-arrestin介导的信号通路不断深入地了解,G蛋白耦联受体(G protein-coupled receptors,GPCR)偏爱性信号转导为研发更加高效、安全的高选择性药物提供了全新的思路。近年来G蛋白偏向型或β-arrestin偏向型配体不断涌现,尤其β-arrestin偏向型配体在治疗神经精神疾病中显示出巨大的应用前景。β-arrestin is involved in multiple physiological and pathological processes,such as cardiovascular and gastrointestinaldiseases,kidney and lung dysfunction,inflammation and metabolic disorders,bone mineral homeostasis maintenance,reproductive andcentral nervous system diseases.With the in-depth understanding ofβ-arrestin mediated pathways,G protein-coupled receptors(GPCR)biased signal transduction gives us an insight into the development of selective drugs with higher efficiency and fewer sideeffects.In recent years,G protein-biased orβ-arrestin-biased ligands have continuously emerged.Especially,β-arrestin-biased ligandshave shown great application prospects in treating neuropsychiatric diseases.

关 键 词：Β-ARRESTIN G蛋白偶联受体 精神分裂症 抑郁症 阿尔茨海默病 帕金森病 

分 类 号：R329.26[医药卫生—人体解剖和组织胚胎学]