单宁酸铁包裹的载全氟己烷纳米粒三模态成像的实验研究  

Tri-modal Imaging of Perfluorohexane Nanoparticles Coated With Iron and Tannic Acid

作　　者：鞠丰翼 袁勋 乔斌 王志刚[2] 张玙[1] 杜之渝[1] JüFengyi;Yuan Xun;Qiao Bin;Wang Zhigang;Zhang Yu;Du Zhiyu(Department of Ophthalmology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China;Chongqing Key Laboratory of Ultrasound Molecular Imaging,Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院,重庆市400010 [2]重庆医科大学超声分子影像重庆市重点实验室

出　　处：《中国超声医学杂志》2020年第6期568-570,共3页Chinese Journal of Ultrasound in Medicine

基　　金：重庆市科学技术委员会基础与前沿项目(No.cstc2018jcyjAX0562)。

摘　　要：目的制备一种三模成像纳米粒,评价其光声/超声/磁共振成像效果。方法制备载单宁酸铁(Fe~ⅢTA)并包裹全氟己烷(PFH)的PLGA纳米粒。检测其相关表征。体外评估Fe~ⅢTA/PLGA/PFH纳米粒在激光辐照后的温度变化和超声信号变化。激光激发后进行光声信号采集。并对不同Fe浓度纳米粒MRI成像。结果成功制备Fe~ⅢTA/PLGA/PFH纳米粒,其粒径为(229.4±37.94)nm,电位为(-17.6±7.64)mV。激光辐照后,纳米粒温度升高,超声成像提示回声强度明显增强;激光辐照后,光声成像检测到明显的光声信号;磁共振成像显示Fe~ⅢTA/PLGA/PFH纳米粒在T1W1呈高信号。结论成功制备Fe~ⅢTA/PLGA/PFH纳米粒,具有良好的光热效应,具有良好的体外光声/超声/磁共振成像效果。Objective To prepare a tri-model imaging nanoparticles and explore its photoacoustic,ultrasonic and MR imaging ability.Methods The nanoparticles containing PLGA shell,Fe~ⅢTA and PFH were prepared.In addition,the characterization were measured.The temperature and ultrasound signal change were evaluated after near-infrared laser irradiation different concentration.Fe~ⅢTA/PLGA/PFH nanoparticles in different concentration was prepared.The photoacoustic signal of nanoparticles was detected.MR imaging ability of nanoparticles in different concentration of Fe was detected.Results Fe~ⅢTA/PLGA/PFH nanoparticles were prepared.The average particle size of nanoparticles was(229.4±37.94)nm and the mean surface charge was(-17.6±7.64)mV.The temperature of nanoparticles increased when applying irradiation and ultrasound imaging indicated that the echo intensity was significantly enhanced.The photoacoustic signal was detected increasingly after irradiation.MRI signal of nanoparticles was high in T1 W1.Conclusions The Fe~ⅢTA/PLGA/PFH nanoparticles were prepared.Such particles possess excellent photothermal effect,photoacoustic imaging effect,ultrasound imaging effect along with MR imaging effect.

关 键 词：纳米粒 光声成像 磁共振成像 超声分子成像 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R445.1[医药卫生—影像医学与核医学]