脑老化对大脑皮质语言区偏侧性影响的MRI研究  

MRI study of the effect of brain aging on the laterality of language division in cerebral cortex

作　　者：夏新建 王辉[2] 汤煜春 林祥涛[1] 张忠和[1] 孙博[4] 于乔文 刘树伟 王锡明[1] 侯中煜[1] XIA Xinjian;WANG Hui;TANG Yuchun;LIN Xiangtao;ZHANG Zhonghe;SUN Bo;YU Qiaowen;LIU Shuwei;WANG Ximing;HOU Zhongyu(Department of Medical Imaging,Shandong Provincial Hospital Affiliated of Shandong University,Shandong Provincial Hospital Affiliated of Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东大学附属省立医院山东第一医科大学附属省立医院医学影像科,山东济南250021 [2]山东省寿光市人民医院CT磁共振室,山东寿光262700 [3]山东大学断层影像解剖学研究中心,山东济南250021 [4]山东省医学影像学研究所,山东济南250021

出　　处：《中国中西医结合影像学杂志》2020年第4期338-341,368,共5页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金(81001223);山东省优秀中青年科学家科研奖励基金(BS2010YY048);山东省重点研发计划(2017GSF218077);山东省医药卫生科技发展计划(2106WS0435);潍坊市科技发展计划(2019YX093);潍坊市卫健委科研项目(wfwsjk_2019_220)。

摘　　要：目的 :应用MRI结构像和计算机图像分析技术探讨大脑语言区皮质体积、厚度及表面积与年龄的相关性及不同年龄段皮质的侧化差异。方法:招募右利手、汉族、18岁及以上的健康志愿者286例,获取其脑3.0 T MRI原始数据;选择额中回、额下回岛盖部、额下回三角部、中央前回、角回、颞上回作为ROI,使用Free Surfer脑成像软件分析得到语言区相关脑回皮质体积、厚度、表面积具体数值;探究青年组(18~40岁)、中年组(41~60岁)、老年组(> 60岁)3个年龄段大脑皮质语言区的偏侧性,同时揭示大脑语言区皮质与年龄的相关性。结果:脑语言区皮质体积、厚度、表面积与年龄均呈负相关,3个形态学指标的年龄相关性相互关联;脑语言区皮质同一形态学指标在不同年龄组的偏侧区域数量不同,出现保留、增加、消失的现象;同一年龄组不同皮质形态学指标偏侧脑区数量不同,皮质体积及表面积偏侧区域数量较皮质厚度多;3个皮质形态学指标中均存在部分脑区的偏侧性持续出现在3个年龄组中,但其偏侧程度(侧化指数)并不相同。结论:语言区皮质结构是不对称的,其偏侧性随着年龄的变化而呈动态改变,不同形态学指标改变模式不同。Objective:MRI and computer image analysis were used to explore the age-related volume,thickness,and surface area of the cerebral language cortex and the lateralization differences of the cortex in different age groups.Methods:286 healthy volunteers over 18 years old were recruited from the right-handed Han nationality to obtain the original data of brain3.0 T MRI.The middle frontal gyrus,inferior frontal gyrus insula,inferior frontal gyrus triangle,central anterior gyrus,angular gyrus and superior temporal gyrus were selected as ROIs.The specific values of volume,thickness and surface area of the gyrus cortex related to language area were analyzed by Free Surfer brain imaging software.The laterality of language division in cerebral cortex of the youth group(18~40 years old),the middle-aged group(41~60 years old) and the elder group(over60 years old) were explored.At the same time,it reveals the age-related of the cerebral language area.Results:The volume,thickness and surface area of the cerebral linguistic cortex were negatively correlated with age,and the age-related correlations of the three morphological indexes were interrelated.The same morphological index of the cerebral linguistic cortex in different age groups had different numbers of laterals,which showed the phenomenon of retention,increase and disappearance.The number of laterals of different cortical morphological indexes in the same age group was different,with different cortical volume and surface area.The number of lateralized areas was more than that of cortical thickness,and the laterality of some brain areas in all three cortical morphological indexes continued to appear in the three age groups,but the degree of lateralization(lateralization index) was not the same.Conclusions:The cortical structure of the language area is asymmetric,its laterality changes dynamically with age,and the change patterns of different morphological indexes are different.

关 键 词：磁共振成像 脑老化 偏侧性 皮质体积 皮质厚度 皮质表面积 感兴趣区 

分 类 号：R445.2[医药卫生—影像医学与核医学] R741[医药卫生—诊断学]