Convergent genomic signatures of high-altitude adaptation among domestic mammals  

作　　者：Dong-Dong Wu Cui-Ping Yang Ming-Shan Wang Kun-Zhe Dong Da-Wei Yan Zi-Qian Hao Song-Qing Fan Shu-Zhou Chu Qiu-Shuo Shen Li-Ping Jiang Yan Li Lin Zeng He-Qun Liu Hai-Bing Xie Yun-Fei Ma Xiao-Yan Kong Shu-Li Yang Xin-Xing Dong Ali Esmailizadeh David M Irwin Xiao Xiao Ming Li Yang Dong Wen Wang Peng Shi Hai-Peng Li Yue-Hui Ma Xiao Gou Yong-Bin Chen Ya-Ping Zhang 

机构地区：[1]State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223,China [2]Key Laboratory of Animal Nutrition and Feed Science of Yunnan Province,Yunnan Agricultural University,Kunming 650201,China [3]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223,China [4]Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,China [5]Kunming College of Life Science,University of Chinese Academy of Sciences,Kunming 650204,China [6]State Key Laboratory for Conservation and Utilization of Bio-resource,Yunnan University,Kunming 650091,China [7]Department of Pathology,the Second Xiangya Hospital,Central South University,Changsha 410011,China [8]Department of Animal Science,Faculty of Agriculture,Shahid Bahonar University of Kerman,Kerman,PB 76169-133,Iran [9]Department of Laboratory Medicine and Pathobiology,University of Toronto,Toronto,M5S 1A8,Canada [10]Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming 650223,China [11]CAS Key Laboratory of Computational Biology,CAS-MPG Partner Institute for Computational Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China

出　　处：《National Science Review》2020年第6期952-963,共12页国家科学评论（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(91731304,31621062);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13000000);YBC was supported by grants from the National Natural Science Foundation of China(81322030,31271579);the Yunnan Province High-level Talents Introduced Program and Yunnan Applied Basic Research Projects(2014FA038);XG was supported by Chinese 863 program(2013AA102503),and the National Natural Science Foundation of China(31260542,31260543,31160449,31460581,31560617);YHM was supported by the National Natural Science Foundation of China(31272403);DDW was supported by Qinghai Department of Science and Technology Major Project‘Sanjiangyuan National Park Animal Genome Project’.

摘　　要：Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence.Here,we used 327 genomes from horses,sheep,goats,cattle,pigs and dogs living at both high and low altitudes,including 73 genomes generated for this study,to disentangle the genetic mechanisms underlying local adaptation of domestic mammals.Although molecular convergence is comparatively rare at the DNA sequence level,we found convergent signature of positive selection at the gene level,particularly the EPAS1 gene in these Tibetan domestic mammals.We also reported a potential function in response to hypoxia for the gene C10 orf67,which underwent positive selection in three of the domestic mammals.Our data provide an insight into adaptive evolution of high-altitude domestic mammals,and should facilitate the search for additional novel genes involved in the hypoxia response pathway.

关 键 词：high altitude Tibetan Plateau genome convergent evolution domestic animals 

分 类 号：Q953[生物学—动物学]