Comparative genomics reveal shared genomic changes in syngnathid fishes and signatures of genetic convergence with placental mammals  

作　　者：Yan-Hong Zhang Vydianathan Ravi Geng Qin He Dai Hui-Xian Zhang Feng-Ming Han Xin Wang Yu-Hong Liu Jian-Ping Yin Liang-Min Huang Byrappa Venkatesh Qiang Lin 

机构地区：[1]CAS Key Laboratory of Tropical Marine Bio-resources and Ecology,South China Sea Institute of Oceanology,Innovation Academy of South China Sea Ecology and Environmental Engineering,Chinese Academy of Sciences,Guangzhou 510301,China [2]Comparative and Medical Genomics Laboratory,Institute of Molecular and Cell Biology,A∗STAR 138673,Singapore [3]Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou),Guangzhou 511458,China [4]Biomarker Technologies Corporation,Beijing 101300,China [5]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《National Science Review》2020年第6期964-977,共14页国家科学评论（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(41825013 and 41890853);the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(GML2019ZD0407);the K.C.Wong Education Foundation,the Key Research Program of Frontier Sciences of CAS(ZDBSLY-DQC004);Innovation Academy of South China Sea Ecology and Environmental Engineering,Chinese Academy of Sciences(ISEE2018PY03);The work in BV’s lab was supported by the Biomedical Research Council of A∗STAR,Singapore.

摘　　要：Syngnathids(seahorses,pipefishes and seadragons)exhibit an array of morphological innovations including loss of pelvic fins,a toothless tubular mouth and male pregnancy.They comprise two subfamilies:Syngnathinae and Nerophinae.Genomes of three Syngnathinae members have been analyzed previously.In this study,we have sequenced the genome of a Nerophinae member,the Manado pipefish(Microphis manadensis),which has a semi-enclosed brood pouch.Comparative genomic analysis revealed that the molecular evolutionary rate of the four syngnathids is higher than that of other teleosts.The loss of all but one P/Q-rich SCPP gene in the syngnathids suggests a role for the lost genes in dentin and enameloid formation in teleosts.Genome-wide comparison identified a set of 118 genes with parallel identical amino acid substitutions in syngnathids and placental mammals.Association of some of these genes with placental and embryonic development in mammals suggests a role for them in syngnathid pregnancy.

关 键 词：Manado pipefish whole-genome sequencing transposable elements placenta-like structure convergent evolution 

分 类 号：Q953[生物学—动物学]