AMPK对线粒体质量的调控作用  

The Role of AMPK in Mitochondria Quality Control

作　　者：杨鑫宇 高树新[1] 贾振伟[1] YANG Xinyu;GAO Shuxin;JIA Zhenwei(College of Animal Science and Technology,Inner Mongolia University for the Nationalities,Tongliao 028043,China)

机构地区：[1]内蒙古民族大学动物科技学院,通辽028043

出　　处：《中国细胞生物学学报》2020年第5期881-887,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金地区基金(批准号:31760670);内蒙古自然科学基金(批准号:2019LH03018);内蒙古自治区研究生科研创新项目(批准号:S2018111999Z)资助的课题。

摘　　要：线粒体是哺乳动物细胞内重要细胞器,通过生物合成、分裂/融合及线粒体自噬过程之间的平衡来维持线粒体质量,其功能异常将导致多种疾病的发生。腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是感受细胞能量变化的关键分子,细胞能量胁迫条件下激活AMPK调控了线粒体的功能,并影响细胞能量代谢和机体的健康,提示AMPK是调控线粒体质量的重要因子。基于此,该文综述了AMPK的结构和激活因素,围绕线粒体生物合成、分裂/融合的动力学和自噬讨论AMPK对哺乳动物细胞线粒体质量的调控作用,为通过激活AMPK而调控线粒体质量,从而为维持机体健康、降低疾病发生提供理论依据。Mitochondria are one of the important intracellular organelles in mammals that maintain mitochondria quality by regulating mitochondria biogenesis,fusion/fission and mitophagy processes.However,mitochondrial dysfunction will lead to the occurrence of various diseases.AMPK(AMP-activated protein kinase)is a key sensor of cellular energy status that is activated in response to energy stress,and regulates mitochondrial function,thereby affecting cell energy metabolism and health of organisms,suggesting that AMPK is an important regulator of mitochondrial quality.Hence,this review focuses on the structure and activation of AMPK,and its roles in the control of mitochondria quality in mammal cells,which may provide reference for modulating mitochondria quality by activating AMPK,thereby maintaining health of organisms and reducing disease incidence.

关 键 词：AMPK 线粒体生物合成 线粒体动力学 线粒体自噬 

分 类 号：Q244[生物学—细胞生物学]