加味越鞠丸治疗糖尿病前期30例临床观察  

Clinical effect of Jiawei Yueju pills in treatment of prediabetes:An analysis of 30 cases

作　　者：陈琪[1] 尹丽花 毛叶[1] 卜献春[1] CHEN Qi;YIN Lihua;MAO Ye;BU Xianchun(The Affiliated Hospital of Hunan Academy of Chinese Medicine,Changsha 410006,Hunan,China;Shaoyang Municipal Hospital of Traditional Chinese Medicine,Shaoyang 422001,Hunan,China)

机构地区：[1]湖南省中医药研究院附属医院,湖南长沙410006 [2]邵阳市中医医院,湖南邵阳422001

出　　处：《湖南中医杂志》2020年第6期9-11,共3页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省中医药管理局一般课题(2014140);湖南省中医药管理局重点课题(201607)。

摘　　要：目的:探讨加味越鞠丸治疗糖尿病前期气滞痰阻证的临床疗效。方法:选取60例糖尿病前期气滞痰阻证患者,将其随机分为治疗组和对照组,每组各30例。在基础治疗(饮食+运动)上,治疗组予加味越鞠丸治疗,对照组予二甲双胍缓释片治疗,疗程均为8周。观察比较2组综合疗效及血糖、血脂、高敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、免疫球蛋白(Ig)E水平。结果:总有效率治疗组为83.33%(25/30),对照组为86.67%(26/30),组间比较,差异无统计学意义(P>0.05)。2组治疗后血糖、血脂、炎性因子、IgE均优于治疗前(P<0.05);治疗后治疗组低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、炎性因子、IgE与对照组比较,差异均有统计学意义(P<0.05)。结论:加味越鞠丸治疗糖尿病前期气滞痰阻证有较好的临床疗效,能降低血糖、调节血脂、改善炎症反应,调节免疫功能。Objective:To investigate the clinical effect of Jiawei Yueju pills in the treatment of prediabetes with Qi stagnation and phlegm obstruction.Methods:A total of 60 patients with prediabetes with Qi stagnation and phlegm obstruction were randomly divided into treatment group and control group,with 30 patients in each group.In addition to basic treatment(dietary intervention and exercise),the patients in the treatment group were given Jiawei Yueju pills,and those in the control group were given metformin sustained-release tablets;the course of treatment was 8 weeks for both groups.The two groups were compared in terms of overall response and levels of blood glucose,blood lipids,high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and immunoglobulin E(IgE).Results:There was no significant difference in overall response rate between the treatment group and the control group[83.33%(25/30)vs 86.67%(26/30),P>0.05].Both groups had significant improvements in blood glucose,blood lipids,inflammatory factors,and IgE after treatment(P<0.05),and there were significant differences between the two groups in low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,inflammatory factors,and IgE after treatment(P<0.05).Conclusion:Jiawei Yueju pills have a good clinical effect in the treatment of prediabetes with Qi stagnation and phlegm obstruction and can reduce blood glucose,regulate blood lipids,improve inflammatory response,and regulate immune function.

关 键 词：糖尿病前期 气滞痰阻证 中西医结合疗法 加味越鞠丸 

分 类 号：R259.871[医药卫生—中西医结合]